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 (ôk′sə-trŏf, -trōf′)
An organism, such as a strain of bacteria, that has lost the ability to synthesize certain substances required for its growth and metabolism as the result of mutational changes.

[Back-formation from auxotrophic.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Microbiology) a mutant strain of microorganism having nutritional requirements additional to those of the normal organism
ˌauxoˈtrophic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Metabolically, SCVs have been described as auxotrophs of haemin, menadione, and thymidine.
Li et al., "Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium," Proceedings of the National Academy of Sciences of the United States of America, vol.
actively acquire host cholesterol for synthesis of cell membranes and other structures and/or are strict auxotrophs for specific forms of cholesterol such as HDL-C and LDL-C.
Whitman, "Method for isolation of auxotrophs in the methanogenic archaebacteria: role of the acetyl-CoA pathway of autotrophic C[O.sub.2] fixation in Methanococcus maripaludis," Proceedings of the National Academy of Sciences of the United States of America, vol.
Auxotrophs were then screened for their ability to produce alginate (Butt et al., 2011).
Chlamydospore production and germ-tube formation by auxotrophs of candida albicans.
Nakamaya [16] cultured Brevibacterium and Corynebacterium auxotrophs on 20-40oC and reported maximum lysine production 17- 39g/L at 30oC that is also in support of our optimized temperature.
Insects are cholesterol auxotrophs [148] and do not contain the amounts of cholesterol required for liposome fusion [149].
Yeast Nitrogen Base with ammonium sulphate and without amino acids (YNB medium; Sigma-Aldrich) was prepared at a concentration of 0.67% and was supplemented with 2% glucose, 10 mM uridine and uracil, and 0.1% 5-FOA (Sigma) to use in screening of auxotrophs.
In filamentous fungi, pyrimidine auxotrophs obtained through inactivation of the OMP decarboxylase gene (usually designated pyrG) are auxotrophic for uridine and/or uracil and are resistant to 5-FOA [5, 6].