The first drug used in the treatment of HIV was azidothymidine
Oral mucosa pigmentation: A new side effect of azidothymidine
therapy in patients with acquired immunodeficiency syndrome.
That same year, contrary to the WHO recommendation (29) to use Tenofovir rather than Azidothymidine
(AZT) as first-line treatment, because it was "less toxic", this was not implemented in Mozambique, because supply was already being met by provision of partner-donated AZT30.
Subsequently, employing the Cu (I) catalyzed click chemistry, the alkynylated coumarin intermediates were subjected to cycloaddition with the azidothymidine
compound (31) to obtain 1,2,3-triazole moieties (32a-e).
Macrocytic anaemia was, however, more common among HIV-infected patients, most likely due to the use of azidothymidine
the virus entry inhibitor dextran sulfate 5000, the broad antiviral agent ribavirin, the antiherpetic drug ganciclovir, and the HIV inhibitor azidothymidine
. After 3-6 days incubation at 37[degrees]C (or 35[degrees]C in the case of INF virus), the cultures were examined by microscopy to score the compounds' inhibitory effect on virus-induced cytopathic effect or their cytotoxicity.
This was not changed with additional azidothymidine
, which has been reported to increase the efficiency for NHEJ  (not shown).
Grieco et al., "The efficacy of azidothymidine
(AZT) in the treatment of patients with AIDS and AIDS-related complex.
have also proven that EGCG inhibit reverse transcriptase and act synergistically with another reverse transcriptase inhibitor, namely, azidothymidine
Other examples of substances of particular public interest about which NTP provided critical research findings include AZT (azidothymidine
) and a number of drug combinations used to prevent mother-to-child transmission of HIV (human immunodeficiency virus); fluoride; polychlorinated biphenyls; hexavalent chromium; acrylamide; silicone fluid used in breast implants; and phenolphthalein, which was once used in laxatives.
He was the guinea pig, one of many who took the first HIV drug: AZT (azidothymidine
), which was fast-tracked by the FDA in 1987 as thousands were dying.
The management of HIV/AIDS, which involves medications such as Azidothymidine
(AZT), has been reported to have adverse effect on the auditory function of individuals infected with HIV/AIDS.