have multiple resistance to tetracycline, fluoroquinolones, and b-lactam
among others (9).
AmpC beta (b)-lactamases are clinically substantial enzymes and are associated with the resistance to a large variety of b-lactam
drugs except carbapenems and cefepime.1 AmpC b-lactamases are clinically significant as they can hydrolyse penicillins, cephalosporins and cephamycins.
Spero Therapeutics announced results from the company's Phase 1b drug-drug interaction trial of SPR741, the first product candidate from its Potentiator Platform, demonstrating pharmacokinetic compatibility and tolerability when co-administered with b-lactam
Understanding and detecting b-lactam
antibiotics resistance and resistance genes and elucidating the drug-resistant mechanism is of significance to prevention and treatment of avian Escherichia coli disease.
The development of fast and accurate diagnostic methods to detect antibiotic resistance genes is needed to minimise antibiotic resistance.b-Lactam antibiotics are some of the most successful drugs used for the treatment of bacterial infections and represent roughly 65% of the total world market for antibiotics.1 Therefore, resistance to b-lactam
antibiotics through the acquisition of genes that encode b-lactamases is one of the most serious problems in Gram-negative pathogenic bacteria.
Shah and coworkers found that 95% of the isolates studied lacked mecA, which is the gene that confers B-lactam
In a large case series of pregnant women with listeriosis, most patients were given a b-lactam
antimicrobial drug, with or without gentamicin (6).
The percentage of resistance against third- generation cephalosporins, extended spectrum penicillins and other b-lactam
antibiotics was very high.
In addition, residues of antibiotics previously produced in the pharmaceutical facility, such as B-lactam
derivatives, are also able to inhibit microbial growth on contact plates.
Spread of B-lactam
resistant Pseudomonas aeruginosa in cystic fibrosis clinic Lancet 1996; 348: 639-642.
Role efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to b-lactam