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Related to b-lactam: Cephalosporins


 (bā′tə-lăk′təm, bē′-)
1. A lactam composed of a four-membered ring, formed by intramolecular condensation of an amino acid in which the amino group is located at the beta position, or any compound containing this group.
2. A beta-lactam antibiotic.

[beta, second (in the series of lactam rings, the first being the simplest) + lactam.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
have multiple resistance to tetracycline, fluoroquinolones, and b-lactam among others (9).
AmpC beta (b)-lactamases are clinically substantial enzymes and are associated with the resistance to a large variety of b-lactam drugs except carbapenems and cefepime.1 AmpC b-lactamases are clinically significant as they can hydrolyse penicillins, cephalosporins and cephamycins.
Spero Therapeutics announced results from the company's Phase 1b drug-drug interaction trial of SPR741, the first product candidate from its Potentiator Platform, demonstrating pharmacokinetic compatibility and tolerability when co-administered with b-lactam antibiotics.
Understanding and detecting b-lactam antibiotics resistance and resistance genes and elucidating the drug-resistant mechanism is of significance to prevention and treatment of avian Escherichia coli disease.
The development of fast and accurate diagnostic methods to detect antibiotic resistance genes is needed to minimise antibiotic resistance.b-Lactam antibiotics are some of the most successful drugs used for the treatment of bacterial infections and represent roughly 65% of the total world market for antibiotics.1 Therefore, resistance to b-lactam antibiotics through the acquisition of genes that encode b-lactamases is one of the most serious problems in Gram-negative pathogenic bacteria.
Shah and coworkers found that 95% of the isolates studied lacked mecA, which is the gene that confers B-lactam antibiotic resistance.
In a large case series of pregnant women with listeriosis, most patients were given a b-lactam antimicrobial drug, with or without gentamicin (6).
The percentage of resistance against third- generation cephalosporins, extended spectrum penicillins and other b-lactam antibiotics was very high.
In addition, residues of antibiotics previously produced in the pharmaceutical facility, such as B-lactam derivatives, are also able to inhibit microbial growth on contact plates.
Role efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to b-lactam resistance.