Against this backdrop, a recent study published in the Journal of the American Medical Association (JAMA) concluded that administration of cranberry capsules daily for one year had no significant effect on the presence of bacteriuria
plus pyuria in elderly women living in nursing homes.
is defined as the presence of 10 (5) colony forming units (ie, viable bacteria) per milliliter of urine collected midstream on 2 consecutive urinations.
is more common in diabetics than in non-diabetics due to a combination of host and local risk factors.
The authors tested the effect of two oral cranberry capsules daily on the presence of bacteriuria
plus pyuria among 185 women aged >65 years with or without bacteriuria
plus pyuria living in nursing homes using a double-blind, randomised, placebo-controlled efficacy trial over 1 year.
(1,7) For these kind of procedures, the main complications are bacteriuria
, urinary infection and, more rarely, bacteremia and sepsis.
"This trial did not show a benefit of cranberry capsules in terms of lower presence of bacteriuria
plus pyuria [presence of bacteria and white blood cells in the urine, a telltale sign of a UTI among older women living in nursing homes," the study stated.
Essas infeccoes podem ser agrupadas em quatro entidades clinicas diferentes, de acordo com a localizacao anatomica do agravo, mantendo, todavia, relacoes entre as mesmas: bacteriuria
assintomatica (BA), uretrite, cistite e pielonefrite (DUARTE et al., 2008).
GlobalData's clinical trial report, "Bacteriuria
Global Clinical Trials Review, H1, 2016" provides an overview of Bacteriuria
clinical trials scenario.
Essentially, residents who are not exhibiting symptoms of a UTI should not even be cultured, however, if they are, treatment with antibiotics needs to be thought out carefully as asymptomatic bacteriuria
results in a lot of unnecessary antibiotic use.
to rigorously screen patients for asymptomatic bacteriuria
, which can lead to pyelonephritis.