The clinical features of thin
basement membrane nephropathy.
Goodpasture's syndrome, which afflicts <1 in 1 million persons, involves antiglomerular
basement membrane (anti-GBM) antibodies that act against antigens in the kidneys and lungs.(1) Patients typically present with alveolar bleeding, rapidly progressive acute renal failure with proteinuria,(1) and pulmonary symptoms such as dyspnea and hemoptysis.(2)
Having overcome cell adhesion, migratory cells must penetrate the
basement membrane. Metastatic cells and cells in invasive primary tumors break this barrier by secreting enzymes that destroy membrane collagen; leukocytes are the only normal cells capable of breaching a
basement membrane.
Capillary deposition of complement split product C4d in renal allografts is associated with
basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection.
The reduced collagen expression at the early step of carcinogenesis may cause disturbed keratinocyte adhesion to the
basement membrane (Parikka et al.
The size of the pores within the glomerular
basement membrane serves as the primary barrier to the filtration of plasma proteins (Kanwar, 1984).
"Soybean lysolecithin promoted
basement membrane repair by increasing laminin 5 synthesis in the epidermis," explained I)r.
Previous studies have found that an increased urinary heparan sulfate excretion rate is associated with the loss of
basement membrane anionic charge in diabetic nephropathy (7-10).
The lobes are encased in a protective sheet called the
basement membrane, and in each lobe are long ducts that extend into the insect's mouth.
Morphology of pericytes and the
basement membrane shared with endothelial cells was observed with a transmission electron microscope (JEM-1400PLUS; JEOL, Japan).
Keywords: Pulmonary renal syndrome (PRS), diffuse alveolar haemorrhages (DAH), acute kidney injury (AKI), Antineutrophil cytoplasmic autoantibody (ANCA) associated vasculitis, anti-glomerular
basement membrane (GBM) disease, systemic lupus erythematosus (SLE).
'Surprisingly, we could observe a massive expansion of the
basement membrane in the vascular organoids,' said Wimmer.