The clinical features of thin basement membrane
Goodpasture's syndrome, which afflicts <1 in 1 million persons, involves antiglomerular basement membrane
(anti-GBM) antibodies that act against antigens in the kidneys and lungs.(1) Patients typically present with alveolar bleeding, rapidly progressive acute renal failure with proteinuria,(1) and pulmonary symptoms such as dyspnea and hemoptysis.(2)
Having overcome cell adhesion, migratory cells must penetrate the basement membrane
. Metastatic cells and cells in invasive primary tumors break this barrier by secreting enzymes that destroy membrane collagen; leukocytes are the only normal cells capable of breaching a basement membrane
Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane
injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection.
The reduced collagen expression at the early step of carcinogenesis may cause disturbed keratinocyte adhesion to the basement membrane
(Parikka et al.
The size of the pores within the glomerular basement membrane
serves as the primary barrier to the filtration of plasma proteins (Kanwar, 1984).
"Soybean lysolecithin promoted basement membrane
repair by increasing laminin 5 synthesis in the epidermis," explained I)r.
Previous studies have found that an increased urinary heparan sulfate excretion rate is associated with the loss of basement membrane
anionic charge in diabetic nephropathy (7-10).
The lobes are encased in a protective sheet called the basement membrane
, and in each lobe are long ducts that extend into the insect's mouth.
Morphology of pericytes and the basement membrane
shared with endothelial cells was observed with a transmission electron microscope (JEM-1400PLUS; JEOL, Japan).
Keywords: Pulmonary renal syndrome (PRS), diffuse alveolar haemorrhages (DAH), acute kidney injury (AKI), Antineutrophil cytoplasmic autoantibody (ANCA) associated vasculitis, anti-glomerular basement membrane
(GBM) disease, systemic lupus erythematosus (SLE).
'Surprisingly, we could observe a massive expansion of the basement membrane
in the vascular organoids,' said Wimmer.