Data was recorded and percentages were calculated for qualitative histological variables that include hepatic lobular pattern, central vein congestion, periportal inflammation, vacuolation and
basement membrane continuity.
Kidney sections from the animals in group acrylamide and its derivatives, showed numerous histomorphological alterations that increasing mesangial matrix, cellular degeneration and swelling of the tubular epithelium glomerular hypercellularity, thickening of the glomerular
basement membrane and glycogenic vacuolization in the tubular epithelium.
8],[9],[10] The electron microscope examination revealed that permethrin exposure caused to prominent histomorphometric alterations including vacuolization of Sertoli, and disorganization of the
basement membrane.
Review of the histological findings and direct immunofluorescence examination confirmed the diagnosis of linear IgA bullous dermatosis, an intact skin punch biopsy showing 1 - 2+ linear staining in the region of the epidermal
basement membrane.
b) Irregularity and patchy thickening of
basement membrane (periodic acid shift x200).
DIF studies demonstrated linear IgA (4+) staining in the
basement membrane zone.
The two specimens (before and after FDT), were compared with respect to the
basement membrane pigmentation, percentage of dermis occupied by granuloma or inflammatory infiltrate per average low power field, presence of protective cells such as lymphocytes and epithelioid cells, the presence of acid fast bacilli and evidence of dermal fibrosis.
10 EB simplex is a non-scaring dominant disorder although the type of inheritance is recessive in some subtypes11, the intraepidermal bullae occur due to cytolysis of the basal cells, while in junctional and dystrophic forms the separation occurs through the lamina lucida of the
basement membrane and lamina densa.
DIF microscopy demonstrating IgG and IgM deposits at the
basement membrane zone; and 5.
With repeated episodes of epithelial breakdown and failed attempts at the development of a stable epithelial
basement membrane adhesion complex, morphological changes eventually develop, leading to the classic map-dot-fingerprint epithelial and sub-epithelial findings that characterise this dystrophy.
Data suggests that the amnion
basement membrane closely mimics the
basement membrane of human oral mucosa.
Reduced urinary protein excretion and alleviated damage of podocytes and glomerular
basement membrane were seen in the islet- transplanted rats.
