basement membrane

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Related to basement membrane zone: basal lamina

basement membrane

n.
A thin noncellular layer located between epithelial cells and the connective tissue that underlies them, composed of collagen and other proteins and having a variety of functions including support and filtration.

base′ment mem`brane


n.
a thin, extracellular membrane underlying epithelial tissue.
[1840–50]
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References in periodicals archive ?
DIF shows linear deposits of IgG and/or IgA autoantibodies at the basement membrane zone in a u-serrated pattern.
Upregulation of expression of CD1d receptor by keratinocytes and by antigen presenting cells secondary to epithelial injury, or to inflammation at the basement membrane zone, may cause inactivation of invariant natural killer T (iNKT) cells by CD1d-bound glycolipid antigens.
DIF studies demonstrated linear IgA (4+) staining in the basement membrane zone. There was no significant staining seen with IgG, IgM, C3, fibrin, or albumin.
Another autoimmune bullous disease, with neutrophilic and eosinophilic infiltrate in the skin and linear IgG and C3 deposits along the basement membrane zone, is bullous pemphigoid (BP).
(3) The lupus band test is done using DIF and is a widely used tool for making the diagnosis of DLE based on the distribution of immunoglobulin deposition in the basement membrane zone. (7)
Skin biopsy from the vesicular lesion showed normal epidermis with subepidermal cleft with inflammatory infiltrate at the roof and the floor of the blister, predominantly eosinophils (5, 6) Direct immunofluorescence of the perilesional skin showed a strong linear basement membrane zone (BMZ) band with c3 and a week BMZ IgG.
Based on the level of tissue separation within the cutaneous basement membrane zone there are three major types of EB: simplex, junctional and dystrophic, each of them caused by a genetic mutation and each of them having various subtypes that display individual clinical effects [2].
Epidermolysis Bullosa (EB) is a complex group of genetic disorders characterised by mechanical fragility in the basement membrane zone (1).
His recommended diagnostic criteria include using direct immunofluorescence microscopy to identify linear deposits of IgG or complement component C3 in the epidermal basement membrane zone in patients with subepidermal blistering.