The United States Pharmacopoeia recognises benzalkonium chloride
(BC) as an auxiliary antimicrobial agent .
+ fluazinam and procymidone were the most effective treatments.
Later that year Alcon changed the formulation of their prostaglandin analogue, travoprost (Travatan) and in early 2011 that of travoprost with timolol (Duotrav) replacing the preservative benzalkonium chloride
Raiskup, "Pharmacological modification of the epithelial permeability by benzalkonium chloride
in UVA/Riboflavin corneal collagen cross-linking," Current Eye Research, vol.
* Propylene glycol: Like benzalkonium chloride
, it can cause not only allergic contact dermatitis, but irritant contact dermatitis marked by nonimmunologically related burning and stinging.
Use of benzalkonium chloride
(BC) as an antiseptic should be discontinued, concluded Dr.
The zinc nasal gel consisted of zinc gluconate in an emulsion of benzalkonium chloride
, glycerin, hydroxyethylcellulose, sodium chloride, and sodium hydroxide; its pH level was 7.2.
Imprimis will not dispense these formulations with preservatives such as benzalkonium chloride
, which is typically used in many topical glaucoma drugs.
According to Brian Sansoni, VP-communications and membership and VP-sustainability initiatives, more than a year ago FDA granted a deferral of rulemaking for one year for the three active ingredients that ACI is supporting (benzalkonium chloride
(BAC), benzethonium chloride (BZT) and chloroxylenol (PCMX)).
Eight out of thirteen animals were randomly assigned to receive 10 ml of benzalkonium chloride
0.2% (megacolon group) and five animals received 10 ml NaCl 0.9% (controls), injected both under the serosal tissue, 1 cm from intrinsic sphincter of the rectum for 15 min.
BAC-D provides a nonflammable, nonalcohol-based alternative containing benzalkonium chloride
, a Food and Drug Administration monograph drug, and it doesn't irritate tissue and is proven by major university testing to offer residual protection against germs and bacteria for three or more hours after application, the company says.