The cause of the disease is the accumulation of the toxic beta-amyloid peptide
in brain tissues, which leads to oxidative stress, neuroinflammation, mitochondrial dysfunction, and ultimately - the death of nerve cells.
Buyukserin, "Fabrication of thioflavin-T-modified nanopillared SERS substrates for ultrasensitive beta-amyloid peptide
detection," Journal of Raman Spectroscopy, vol.
Link, "Expression of human beta-amyloid peptide
in transgenic Caenorhabditis elegans," Proceedings of the National Academy of Sciences of the United States of America, vol.
Davila-Rodriguez et al., "Beta-amyloid peptide
in blood clots," in Proceedings of VI Meeting of the Physiol, pp.
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The company said that, drug A inhibits beta-amyloid peptide
polymerization and drug B inhibits the neuro-inflammatory response in patients with amnestic mild cognitive impairment (aMCI) because of suspected AD.
Reduced VEGF levels within this microvascular fraction of the brain by impairing overall angiogenesis and possibly reducing blood-brain barrier permeability could alter the normal homeostatic balance of beta-amyloid peptide
handling, leading to impaired efflux out of the CNS parenchymal compartment leading to net accumulation.
The researchers first created a virtual beta-amyloid peptide
that only contained the last 12 amino acids of the entire Abeta42 protein.
Since then, these have been revealed as accumulations of two separate proteins in the brain: beta-amyloid peptide
and tau proteins.
The SORL1 gene is a coding gene for a protein involved in the production of the beta-amyloid peptide
. This protein is known to affect the functioning of the brain cells (see insert).
Two of the identified mutations are responsible for an under-expression of SORL1, resulting in an increase in the production of the beta-amyloid peptide
. "The mutations observed on SORL1 seem to contribute to the development of early-onset Alzheimer's disease.
Disease-modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide
. In Biochem.