Signs of the beta-amyloid protein
were found in the brains of seven patients aged 36 to 51 who had died from Creutzfeldt-Jakob Disease (CJD) after receiving growth hormone from the pituitary glands of dead people.
Researcher Abha Chauhan, PhD, and associates say an extract in the nuts may provide a protective effect against oxidative damage caused by beta-amyloid protein
In both studies, scientists looked for signs of beta-amyloid protein
, which forms clumps in the brains of Alzheimer's patients and is a key hallmark of the disease.
is the primary material found in the sticky brain "plaques" characteristic of Alzheimer's disease.
For example, using brain PET imaging in conjunction with a specialized chemical that binds to beta-amyloid protein
, the buildup of the protein as plaques in the brain can be revealed years before symptoms appear.
In Alzheimer's, the gene is assumed to affect the metabolism of the beta-amyloid protein
, slowing clearance and causing it to clump onto neurons.
Professor Martins is credited, in collaboration with Australian and German scientists, with isolating beta-amyloid protein
, which forms amyloid plaque deposits in the brain, a characteristic diagnostic feature of Alzheimer's disease.
Alzheimer's is marked by deposits of beta-amyloid protein
in the brain, and knotty protein structures in the nerves called tau tangles.
Now, using new research techniques, scientists have shown that a two-molecule aggregate (or dimer) of beta-amyloid protein
fragments may play a role in initiating the disease.
Today, the beta-amyloid protein
is what most researchers believe is the cause of Alzheimer's disease.
Researchers used mice genetically engineered to accumulate waxy plaques of beta-amyloid protein
in their brains, a symptom of Alzheimer's disease in people.
Besides the Company's Synuclere[TM] program, in late pre-clinical development for the treatment of Parkinson's disease, ProteoTech is developing Exebryl-1[R] for the treatment of diseases caused by beta-amyloid protein
and tau protein aggregates and fibrils; and is in early human clinical studies with Systebryl[TM] for the treatment of Systemic AA Amyloidosis.