(https://www.medicalnewstoday.com/articles/326001.php) Using mass spectrometry on blood samples , the new test detects the presence of two forms of the beta-amyloid protein
: beta-amyloid 42 and beta-amyloid 40.
Walker and his colleagues found that adults reporting a decline in sleep quality in their 40s and 50s had more beta-amyloid protein
in their brains later in life, as measured by positron emission tomography, or PET.
"The existing Alzheimer's disease diagnosis technologies have focused on beta-amyloid protein
The pathology underlying AD is associated with a buildup of abnormal beta-amyloid protein
, which clumps together and forms plaque in the brain.
Microglia, neuroinflammation and beta-amyloid protein
in Alzheimer's disease.
APP breaks up to form the famous beta-amyloid protein
and the much less famous AICD protein.
Aducanumab, an antibody, clears away sticky beta-amyloid protein
deposits in the brain that are linked to dementia.
So our findings may have implications for intellectual disorders such as Fragile X Syndrome, which seem to involve too much protein production, and possibly for neurodegenerative disorders such as Alzheimer's in which clumps of beta-amyloid protein
may block neuron-to-neuron signaling at synapses."
Two potential sources of chronic stress are the accumulation of clumps of beta-amyloid protein
in the brain, a known hallmark of Alzheimer's, and diseased arteries which are also linked to dementia.
SAN DIEGO, Calif, January 8, 2016 -- Investigators here have discovered that high sugar caused by Type 2 (adult-onset) diabetes and the beta-amyloid protein
associated with Alzheimer's disease induce the same pathological modification on multiple enzymes in the brain.
Signs of the beta-amyloid protein
were found in the brains of seven patients aged 36 to 51 who had died from Creutzfeldt-Jakob Disease (CJD) after receiving growth hormone from the pituitary glands of dead people.
Researcher Abha Chauhan, PhD, and associates say an extract in the nuts may provide a protective effect against oxidative damage caused by beta-amyloid protein
. A build-up of this protein leads to beta-amyloid plaque, which is believed to play a major role in the development of the disease.