Two major factors responsible for this kind of infection are use of mechanical ventilation and use of beta-lactam antibiotics
. Beta-lactam antibiotics
include Cephalosporins, Penicillins, monobactams and Carbapenems.
Empirical treatment of nosocomial UTIs consists of examination of bacterial spectrum and antibiotics sensitivity testing.1 All over the world, resistance against beta-lactam antibiotics
is increasing due to Extended Spectrum Beta Lactamases (ESBLs) and Amp-c beta-lactamase production.
Hahn and colleagues recruited 20 patients between 1 to 21 years of age who were treated for APEs with beta-lactam antibiotics
at Children's National.
The substrates for these enzymes vary substantially, including Beta-lactam antibiotics
and nucleic acids (both DNA and RNA).
The American Academy of Allergy, Asthma & Immunology recommended more widespread and routine performance of penicillin allergy testing in patients with a history of allergy to penicillin or other beta-lactam antibiotics
. (6) Patients who have penicillin allergy histories are more likely to receive drugs, such as clindamycin or a fluoroquinolone, that may carry much greater risks than a beta-lactam antibiotic
NDM-1 is an enzyme that makes microbes impervious to almost all beta-lactam antibiotics
including carbapenems, which are a backbone for the treatment of antibiotic-resistant bacterial infections.
Summary: New Delhi [India], Dec 17 (NewsVoir): Effective December 10, 2018 Centrient Pharmaceuticals is the new name for DSM Sinochem Pharmaceuticals, the leading manufacturer of beta-lactam antibiotics
and a provider of next-generation statins and anti-fungals.
Synthetic Biologics, in consultation with the FDA, has confirmed the key elements of the Phase 3 clinical program to support a marketing application for ribaxamase, the company's first-in-class oral enzyme designed to degrade certain intravenous beta-lactam antibiotics
within the gastrointestinal tract to prevent microbiome damage, Clostridium difficile infection, overgrowth of pathogenic organisms and the emergence of antimicrobial resistance.
The IID572 is a beta-lactamase inhibitor, which can be used in combination with LYS228 or other beta-lactam antibiotics
to expand their use against difficult-to-treat infections caused by a broader spectrum of CRE.
Under the transaction, the candidates include LYS22, a potential best-in-class monobactam against CRE with resistance caused by serine beta-lactamases (SBLs) and/or metallo beta-lactamases (MBLs); IID572 is a novel beta-lactamase inhibitor that may be used in combination with LYS228 or other beta-lactam antibiotics
to use against difficult-to-treat infections caused by a broader spectrum of CRE; as well as MAK181, an oral, first-in-class LpxC inhibitor for pseudomonas infections.
Similar to other beta-lactam antibiotics
, it is time dependent and its antibacterial activity is related to the duration of the maintenance of its free concentration above the minimal inhibitory concentration (MIC) during each dosing interval (referred to as % of T>MIC).
The hospital's EHR system generated a daily list of patients with a history of penicillin allergy who were on second-line options--vancomycin, daptomycin, aztreonam, linezolid, or moxifloxacin--for infections that would be better treated with beta-lactam antibiotics
. An infectious disease pharmacist reviewed their history; if reported penicillin reactions were limited to a nonspecific rash more than 5 years earlier or seemed to be IgE mediated, patients were skin-prick tested to see if they really were allergic.