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 (bā′tə-lăk′tə-mās′, -māz′, bē′-)
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

[beta-lactam, cyclic amide occurring in penicillins (beta + lact(one) + am(ide)) + -ase.]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.beta-lactamase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions


a. beta-lactamasa, enzima que destruye el conjunto de beta-lactam antibióticos penicílicos haciéndolos no efectivos;
beta-lactamase resistanceresistencia de beta-lactamasa, a algunos tipos de penicilina.
References in periodicals archive ?
Although the organisms possessing these enzymes are resistant to combinations of beta-lactams and beta-lactamase inhibitors, they remain susceptible to narrow spectrum (Cephalothin) and extended spectrum cephalosporins (Ceftazidime, Ceftriaxone), carbapenems and monobactams (8).
Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada.
The easiest and most common molecular method used to detect the presence of a [beta]-lactamase belonging to a family of enzymes is PCR with oligonucleotide primers that are specific for beta-lactamase gene.
Interestingly, in the remaining 2 strains, which were clearly MBL positive by phenotypic test (Etest), no other beta-lactamase gene could be found by PCR as specific primers ([bla.
Genetic structures at the origin of acquisition of the beta-lactamase [bla.
Comparison of screening methods for TEM- and SHV-derived extended-spectrum beta-lactamase detection.
Practical methods using Boronic acid compounds for identification of class C beta-lactamase producing Klebsiella pneumoniae and Escherichia coli.
Vabomere addresses gram-negative bacteria that produce beta-lactamase enzymes that have spread in the United States and Europe, particularly the Klebsiella pneumoniae carbapenemase (KPC) enzyme.

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