The product is an injectable beta-lactamase
inhibitor that features selective and potent in vitro activity against both serine- and metallo-beta-lactamases, including ESBL, OXA, KPC, NDM, and VIM enzymes.
Therefore, routine phenotypic validation tests must be performed to distinguish cefoxitin resistance due to loss of porin from the presence of AmpC enzyme and to prevent masking of AmpC's presence of extended-spectrum beta-lactamase
Genetic coding for beta-lactamase
enzymes have mutated consistently in response to heavy pressure of antibiotic usage, ultimately causing to the development of newer broad spectrum [beta]-lactamases.
Entasis Therapeutics Holdings reported initial preliminary results from the first-in-human Phase 1 clinical trial of its novel, oral beta-lactamase
(3) The class A enzymes contain a serine in the active site and their functions are inhibited by beta-lactamase
inhibitors, such as clavulanic acid, tazobactam, and sulbactam.
threat in Enterobacteriaceae, Pseudomonas and Acinetobacter.
The detection of [beta]-lactamases can be done by phenotypic and genotypic detection methods, in phenotypic detection, different methods can be used such as MIC by agar dilution, MIC by E-Test, modified hodge test (MHT), EDTA imipenem combine disc synergy test, Vitec MIC detection (automated), Nitrocefin, a chromogenic cephalosporin substrate which changes color from yellow to red upon beta-lactamase
Today, one challenge faced by the World Health Organization (WHO) is extended-spectrum beta-lactamase
Under the transaction, the candidates include LYS22, a potential best-in-class monobactam against CRE with resistance caused by serine beta-lactamases
(SBLs) and/or metallo beta-lactamases
(MBLs); IID572 is a novel beta-lactamase
inhibitor that may be used in combination with LYS228 or other beta-lactam antibiotics to use against difficult-to-treat infections caused by a broader spectrum of CRE; as well as MAK181, an oral, first-in-class LpxC inhibitor for pseudomonas infections.
Patterns and mechanisms of resistance to beta-lactams and beta-lactamase
inhibitors in uropathogenic Escherichia coli isolated from dogs in Portugal.
Dissemination of CTX-M-type beta-lactamase
among clinical isolates of Enterobacteriaceae in Markazi province, Iran.
Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing SPM-1 metallo beta-lactamase
in a teaching hospital in Southern Brazil.