beta-lactamase


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be·ta-lac·ta·mase

 (bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

[beta-lactam, cyclic amide occurring in penicillins (beta + lact(one) + am(ide)) + -ase.]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.beta-lactamase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Translations

be·ta-lac·ta·mase

a. beta-lactamasa, enzima que destruye el conjunto de beta-lactam antibióticos penicílicos haciéndolos no efectivos;
beta-lactamase resistanceresistencia de beta-lactamasa, a algunos tipos de penicilina.
References in periodicals archive ?
The product is an injectable beta-lactamase inhibitor that features selective and potent in vitro activity against both serine- and metallo-beta-lactamases, including ESBL, OXA, KPC, NDM, and VIM enzymes.
Therefore, routine phenotypic validation tests must be performed to distinguish cefoxitin resistance due to loss of porin from the presence of AmpC enzyme and to prevent masking of AmpC's presence of extended-spectrum beta-lactamase (ESBL).
Genetic coding for beta-lactamase enzymes have mutated consistently in response to heavy pressure of antibiotic usage, ultimately causing to the development of newer broad spectrum [beta]-lactamases.
Entasis Therapeutics Holdings reported initial preliminary results from the first-in-human Phase 1 clinical trial of its novel, oral beta-lactamase inhibitor ETX0282.
(3) The class A enzymes contain a serine in the active site and their functions are inhibited by beta-lactamase inhibitors, such as clavulanic acid, tazobactam, and sulbactam.
The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter.
The detection of [beta]-lactamases can be done by phenotypic and genotypic detection methods, in phenotypic detection, different methods can be used such as MIC by agar dilution, MIC by E-Test, modified hodge test (MHT), EDTA imipenem combine disc synergy test, Vitec MIC detection (automated), Nitrocefin, a chromogenic cephalosporin substrate which changes color from yellow to red upon beta-lactamase mediated hydrolysis10.
Today, one challenge faced by the World Health Organization (WHO) is extended-spectrum beta-lactamase (ESBL)-producing bacteria.
Under the transaction, the candidates include LYS22, a potential best-in-class monobactam against CRE with resistance caused by serine beta-lactamases (SBLs) and/or metallo beta-lactamases (MBLs); IID572 is a novel beta-lactamase inhibitor that may be used in combination with LYS228 or other beta-lactam antibiotics to use against difficult-to-treat infections caused by a broader spectrum of CRE; as well as MAK181, an oral, first-in-class LpxC inhibitor for pseudomonas infections.
Dissemination of CTX-M-type beta-lactamase among clinical isolates of Enterobacteriaceae in Markazi province, Iran.
Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing SPM-1 metallo beta-lactamase in a teaching hospital in Southern Brazil.