In this light, leading biotechnology entity Bicycle Therapeutics, best known for its flagship bicyclic
peptide discovery has recently affirmed its extended collaboration with AstraZeneca to innovate new peptide targets for cardiovascular as well as metabolic disorders.
Antidepressant biochemical profile of the novel bicyclic
compound Wy-45,030, an ethyl cyclohexanol derivative.
Bicycle Therapeutics is developing a unique class of chemically synthesized medicines based on its proprietary bicyclic
peptide (Bicycle) product platform to address therapeutic needs unreachable with existing treatment modalities.
The potency and efficacy of bicyclic
peptide inhibitors of PKal, such as THR-149, have been demonstrated in preclinical studies.
Jorgensen, Discovery and crystallography of bicyclic
arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase, Bioorg.
skeletal vibration absorption peak appeared at 576 [cm.sup.-1] and the bending vibration absorption peak was at 455 [cm.sup.-1].
Li, "Complete characterization of bicyclic
graphs with minimal Kirchhoff index," Discrete Applied Mathematics, vol.
Liu, "Sharp Bounds of the Hyper-Zagreb Index on Acyclic, Unicylic, and Bicyclic
Graphs," Discrete Dynamics in Nature and Society, vol.
Pinnau, "Synthesis and characterization of a microporous 6FDA-polyimide made from a novel carbocyclic pseudo Troger's base diamine: effect of bicyclic
bridge on gas transport properties," Polymer, vol.
Irradiation of their acetonitrile solutions with UV light of 365 nm results in thermally reversible transformation into the ring-closed bicyclic
diaziridine isomers 1-4 C.
lactones having a gem-dimethylcyclopropane system have also been obtained as products of cyclization of [gamma], [delta]-epoxyamide in the presence of lithium diisopropylamide  or 1,3-cyclization of [beta]-chloroisopropyl-[gamma]-lactones with potassium tert-butoxide [37, 38].
The aromatic bicyclic
indole--made of benzene fused to a pyrrole ring--is abundantly present in nature as a metabolic derivative and as an indolyl moiety present in biological molecules utilized by plants, animals, and microbes.