kernicterus

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kernicterus

(ˌkɜːˈnɪktərəs)
n
(Medicine) a medical condition involving a build-up of bilirubin in the brain and neural damage
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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Noun1.kernicterus - an abnormal accumulation of bile pigment in the brain and other nerve tissue; causes yellow staining and tissue damage
icterus, jaundice - yellowing of the skin and the whites of the eyes caused by an accumulation of bile pigment (bilirubin) in the blood; can be a symptom of gallstones or liver infection or anemia
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Translations

ker·nic·ter·us

n. kernícterus, forma de ictericia del recién nacido.
English-Spanish Medical Dictionary © Farlex 2012

kernicterus

n kernicterus m
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
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References in periodicals archive ?
Serum bilirubin and bilirubin/ albumin ratio as predictors of bilirubin encephalopathy. Pediatrics.
Because a reliable test to identify all newborns at risk for developing acute bilirubin encephalopathy is not available (United States Preventive Services Task Force, 2009), the AAP (2004) supports an approach that attempts to balance the risks between failure to identify possible risks of hyperbilirubinemia and those associated with overtreatment.
We know that neonatal hyperbilirubinemia is a medical emergency, because unconjugated bilirubin is neurotoxic in certain concentration and under various conditions and may cause bilirubin encephalopathy or kernicterus.
Acute bilirubin encephalopathy and kernicterus are known to be the two major complications associated with it, resulting in neurotoxic effects, including sensorineural hearing loss, hypotonia, delayed motor skills and intellectual deficits.
However, if serum bilirubin levels exceed a dangerous limit, which varies with birth weight, gestational age, chronological age and internal milieu of the body, bilirubin may cross blood brain barrier and bilirubin encephalopathy results.
This technique shows positive effects in more than 200 medical conditions among which Ataxia, Alzheimer's Disease, Autism, Cerebral palsy, Adrenoleukodystrophy, many types of Epilepsy, color blindness, Macular Degeneration, Retinitis Pigmentosa, Cone-Rod Dystrophy, Vascular Dementia, Leukoencephalopathy, Huntington's disease, Multiple Sclerosis, Parkinson's Disease, Stroke, Bilirubin encephalopathy to name a few.
Ostrow, "The molecular basis of bilirubin encephalopathy and toxicity: report of an EASL Single Topic Conference, Trieste, Italy, 1-2 October, 2004," Journal of Hepatology, vol.
If the concentration of non-conjugated bilirubin in the blood is too high, it breaches the blood brain barrier and bilirubin encephalopathy occurs with serious consequences for the child.
Alex and Gallant (2008) reinforce that as long as the baby is thriving and other pathologies have been ruled out, breast milk jaundice is not known to result in bilirubin encephalopathy. NICE (2010) has specifically recommended research on the link between breastfeeding and jaundice so there may be developments in the evidence available in the near future.
HLCs can also be given before the onset of bilirubin encephalopathy occurs, and can thus provide sufficient amounts of UGT1A1 to allow the liver to metabolize this toxin.
Factors that alter these parameters increase the risk for developing hyperbilirubinaemia and acute bilirubin encephalopathy (ABE).
They address genetics, biochemistry, transport, metabolism of bilirubin, the physiology and epidemiology of neonatal hyperbilirubinemia, public policy measures, clinical management, and interventions for the prevention and treatment of hyperbilirubinemia and bilirubin encephalopathy in low and middle-income countries.