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The degree to which or rate at which a drug or other substance is absorbed or becomes available at the site of physiological activity after administration.

bi′o·a·vail′a·ble (-lə-bəl) adj.


(Medicine) the extent to which a drug or other substance is taken up by a specific tissue or organ after administration; the proportion of the dose of a drug that reaches the systemic circulation intact after administration by a route other than intravenous. Also called: systemic availability
ˌbioaˈvailable adj


(ˌbaɪ oʊ əˌveɪ ləˈbɪl ɪ ti)

the extent to which a substance can be used by the body.
bi`o•a•vail′a•ble, adj.
References in periodicals archive ?
OBJECTIVES: In this study, we assessed arsenic speciation in greenhouse-grown and supermarket-bought rice, and determined arsenic bioavailability in cooked rice using an in vivo swine model.
While the effects of dietary fiber, alcohol, and smoking on bioavailability are discussed for some vitamins, malabsorption in "leaky gut" conditions is not.
An effect that has been proven scientifically: a recent clinical trial compared the relative absorption of CAVAMAXA W8 curcumin with pure curcumin extract (95%) and two commercially available curcumin preparations intended to increase bioavailability.
Oral bioavailability is determined by two major processes: dissolution (where solubility plays an important role) and absorption (governed by permeability).
We will be looking at the bioavailability of the plasma processed protein and it will be a great complement to our first investigation.
In this article, we examined the Brazil's current regulation for prescription drug substitutability in light of the concepts of drug bioavailability, relative bioavailability and bioequivalence.
While big pharma companies will often have the necessary capabilities in-house to achieve this, it may well be outside the scope of a small biotech, and assistance from an organization with expertise in formulating candidates with bioavailability issues will likely be required.
We chose to measure bioavailability using area under the plasma concentration curve (AUC) because it accurately represents the total amount of unchanged active compounds that reach systemic circulation.
It will now move into a multiple-dose comparative bioavailability study and continues in 12-month stability studies.
Relative bioavailability of P in brown- and yellow-seeded pea was estimated using the slope-ratio technique (Finney 1978).
This unique, naturally-based technology is a catalyst to expand Ashland's comprehensive expertise in biofunctionals gained from our Vincience technology and our core competency in bioavailability.