US-based Xenex's Germ-Zapping Robots were tested recently against live (not surrogate) Ebola virus and Bacillus anthracis (anthrax) spores in collaboration with the biosafety level 4
(BSL-4) containment laboratory at Texas Biomedical Research Institute, the company said.
The pathogen is classified as a biosafety level 4
(BSL-4)  pathogen and should be handled only in high-level biosafety settings (1).
Failure to work in what is deemed a biosafety level 4
lab, of which there are only about two dozen worldwide, would likely not result in successful extraction but almost assuredly death of the handlers.
Working under maximum-containment conditions in a biosafety level 4
facility in UTMB's Galveston National Laboratory, the team introduced mutations into the virus' genetic code at four locations thought to generate proteins that affected immune response.
The NBAF would be the world's fourth Biosafety Level 4
laboratory capable of large animal research, replacing the aging Plum Island Animal Disease Center located off Long Island.
To the Editor: Recently, the directors of Biosafety Level 4
(BSL-4) laboratories in the United States published their views of the requirement of having [greater than or equal to] 2 persons present at all times while biological work is undertaken in a BSL-4 laboratory (1).
Currently, all operational biosafety level 4
(BSL-4) labs are overseen by HHS's Centers for Disease Control and Prevention (CDC).
On May 9, blood samples from 14 acutely ill persons arrived at CDC and were processed in the biosafety level 4
laboratory; analyses included testing for Ebola antigen and Ebola antibody by enzyme-linked immunosorbent assay, and reverse transcription-polymerase chain reaction (RT-PCR) for viral RNA.
laboratory at the University of Texas Medical Branch (UTMB), the only full-sized, maximum containment laboratory on a university campus in the United States and one of just four such Biosafety Level 4
(BSL4) "space suit" laboratories currently operating in the U.
The campus on Clifton Road grew to include 2 biosafety level 4
laboratories and other state-of-the-art facilities; operations were established in Morgantown, Cincinnati, Fort Collins, and overseas; and the work expanded to include all infectious diseases, as well as occupational health, toxic chemicals, injury, chronic diseases, health statistics, and birth defects.
Cytokine measurement in biological samples after physicochemical treatment for inactivation of biosafety level 4
Biosafety Level 4
is the highest containment, which is used for studying diseases such as Ebola.