8) reported the molecular engineering of IQA biosynthesis
The ceramide biosynthesis
pathway is conserved from yeast to man.
After a 24-h exposure of cells to fraction P, protein kinase C activity was inhibited by 70% and a significant increase in extracellular signal-regulated kinases 1 and 2 and c-jun N-terminal kinases expression was observed together with the down-regulation of polyamine biosynthesis
and the activation of caspase-3.
The new drug lead, BPH-703, inhibits a key enzyme in isoprenoid biosynthesis
that enables the malaria parasite to sustain itself and defend itself from the host immune system.
work focused on the isolation and characterization of a malonyltransferase, a putative key enzyme involved in the biosynthesis
of cardiac glycosides.
Ethylene is claimed to be the actual inducer of germination in Striga seeds and that all Striga germination stimulants act through promotion of ethylene biosynthesis
in the parasite seeds [9,2].
of natural colorants from fungi could ensure that colorant production is accomplished under controlled conditions in bioreactors that make the colorant manufacturer independent from the external, seasonal supply of raw materials.
Enzyme technologies; metagenomics, evolution, biocatalysis, and biosynthesis
In addition, tocotrienols demonstrate properties affecting blood lipid levels and help to protect cardiovascular function by altering the biosynthesis
of cholesterol and reducing the oxidation of LDL cholesterol, the company says.
The successful application of biotechnology to the development of marine-derived pharmaceuticals has been met with an increased drive towards elucidating the enzyme pathways that lead to the biosynthesis
of such complex and biologically active molecules.
Agriculture and Agri - Food Canada (Canada) has patented the use of a regulatory gene Lc and encoded protein to alter the biosynthesis
and accumulation of flavonoids including anthocyanins and condensed tannins in plants and plant tissues, particularly in alfalfa, white clover, and other forage legumes which are similar in lacking native condensed tannin accumulation in leaves.
The recently discovered non-mevalonate pathway of isoprenoid biosynthesis
serves as the unique source of terpenoids in numerous pathogenic eubacteria and in apicoplast-type protozoa, most notably Plasmodium, but is absent in mammalian cells.