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Chemical alteration of a substance within the body, as by the action of enzymes.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌbaɪ oʊˌtræns fərˈmeɪ ʃən)

the series of chemical changes occurring in a compound, esp. a drug, as a result of enzymatic or other activity by a living organism.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
(1992) reported the biotransformation of ([+ or -])-(4R)-limonene (64) and (-)-(4S)-limonene (67).
Biotransformation and cytotoxicity of a brominated flame retardant, tetrabromobisphenol A, and its analogues in rat hepatocytes.
* The Biotransformation process in Olea25Tm has no Oleuropein residue in final product
The process, simultaneous enzymatic biotransformation and microbial fermentation, works with cellulose from any plant.
Although CYP2D6 accounts for 2% of the total CYP450 liver enzyme content, it mediates metabolism in 25% to 30% of drugs in common clinical use and has a major influence on the biotransformation of SSRIs (Table, page 18).
Differences in the toxin profile of the toxic dinoflagellates and the tissues of the scallops confirmed biotransformation of PSP algal toxins in the scallop digestive gland, where the majority of the PSP toxins were located.
They discuss the pathophysiology of the diseased hepatic and biliary system that affects other organs and drug biotransformation. Among the topics are functions of the liver, considerations in selecting an inhaled anesthetic agent in liver disease, liver disease in pregnancy, anesthesia for liver transplant, and congenital cholestatic syndromes.
This assumption is based on the findings that rumen microbiota has the biotransformation ability of mycotoxins to less toxic or non toxic metabolites.
Different endpoints that are fundamental in the identification of potential hazards and risks associated with chemicals can be predicted starting from QSAR models, such as the PBT properties (i.e., environmental persistence, bioaccumulation, and toxicity), or biotransformation (i.e., a key determinant for bioaccumulation assessment) in aquatic and terrestrial organisms (Papa et al., 2014, 2018).
First, I provide an overview of essential oils, including modes of application; details on liver biotransformation, metabolism, and excretion throughout the body; medication interactions; and the controversies and inconsistencies regarding various subtopics in aromatherapy.
Genetic polymorphism of CYP3A4 is a susceptibility factor for drug biotransformation reaction.[23],[24],[25] The functional mutation of CYP3A4*1G gives rise to a difference in mRNA expression and resulting changes in drug metabolism rate.