INTRODUCTION: Bisphosphonate-associated osteonecrosis of the jaw, often abbreviated as BON, BON of the jaw or even BRONJ, is a recently discovered dental phenomenon that may lead to surgical complication in the form of impaired wound healing following oral or periodontal surgery or endodontic therapy.
Springer et al., "Actinomycosis of the jaws--histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis," Virchows Archiv, vol.
Actinomycosis of bone is a rare disease that usually result from adjacent soft tissue infection, but may be also associated with trauma, infected osteoradionecrosis, bisphosphonate-associated osteonecrosis and invation of microorganisms throught out periodontal ligament.
Bisphosphonate-associated osteonecrosis of the jaw (BON) is defined as the unexpected development of necrotic bone in the oral cavity of a patient who is receiving bisphosphonate treatment and has not received radiotherapy to the head and neck.
Use of bisphosphonates has been associated with a small risk of developing bisphosphonate-associated osteonecrosis of the jaw (BON) that occurs spontaneously or after the patient has undergone dental surgery.