is endemic in North America in regions bordering the Great Lakes and the St Lawrence, Ohio, and Mississippi rivers.
The biopsy showed no cancer but did reveal signs of an airborne infection common in the Midwest called blastomycosis
. The fungal infection, which can be caused by inhaling decaying leaves or soil, is often harmless.
Infectious causes include Mycobacterium tuberculosis, Yersinia species, Blastomycosis
, Schistosoma species, Actinomyces species, Campylobacter species and Histoplasma capsulatum.
Several names have been used to describe this disease, including lobomycosis, keloidal blastomycosis
, Amazonic blastomycosis
, Jorge Lobo disease, and lacaziosis.
Tolsura is indicated for the treatment of blastomycosis
(pulmonary and extrapulmonary), histoplasmosis (including chronic cavitary pulmonary disease and disseminated, non-meningeal histoplasmosis) and aspergillosis (pulmonary and extrapulmonary, in patients who are intolerant of or who are refractory to amphotericin B therapy).These serious infections most commonly occur in vulnerable or immunocompromised patients, and are often associated with high mortality rates or long-term health issues.
Pulmonary Bulla in a dog secondary to blastomycosis
. Iranian Journal of Veterinary Surgery, v.
Tolsura, a new formulation of itraconazole, is indicated for the treatment of fungal infections in blastomycosis
(pulmonary and extrapulmonary), histoplasmosis (including chronic cavitary pulmonary disease and disseminated, non-meningeal histoplasmosis) and aspergillosis (pulmonary and extrapulmonary).
is a pyogranulomatous infection caused by a dimorphic fungus, Blastomyces dermatitidis.
Chronic infections include Mycobacterium tuberculosis, nontuberculous mycobacteria (with a particular risk group such as elderly women without structural pulmonary disease), chronic necrotic aspergillosis, histoplasmosis, blastomycosis
, paragomiasis, echinococcosis and tracheobronchial papillomatosis.
Fungi were the organisms most commonly identified post mortem, namely Candida (n=2), aspergillosis (n=4), blastomycosis
(n=1) and mucormycosis (n=1).
In October 2017, the New York State Department of Health was alerted by Albany-area infectious disease physicians about local cases of blastomycosis
, including multiple severe infections, in the state health department's Capital District, an area where Blastomyces spp.