blood-brain barrier


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blood-brain barrier

(blŭd′brān′)
n.
A physiological mechanism that alters the permeability of brain capillaries, so that some substances, such as certain drugs, are prevented from entering brain tissue, while other substances are allowed to enter freely.

blood′-brain′ bar`rier


n.
a layer of tightly packed cells that make up the walls of brain capillaries and prevent many substances in the blood from diffusing into the brain.
[1940–45]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.blood-brain barrier - a mechanism that creates a barrier between brain tissues and circulating blood; serves to protect the central nervous system; "the brain was protected from the large molecules of the virus by the blood-brain barrier"
barrier - anything serving to maintain separation by obstructing vision or access
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References in periodicals archive ?
ENPNewswire-August 13, 2019--MIT - Tissue model reveals role of blood-brain barrier in Alzheimer's
The major challenge to CNS drug delivery is the blood-brain barrier (BBB), which limits the access of drugs to the brain substance.
Strategic Research Priority: Bioscience for Health Abstract Several foreign cell types have the intrinsic propensity to cross the mammalian blood-brain barrier and establish themselves in the brain causing various types of disease.
NEW YORK, N.Y., June 6, 2019 -- In a new study, scientists have recreated a critical brain component, the blood-brain barrier, that functioned as it would in the individual who provided the cells to make it.
The FUS technique temporarily opens the blood-brain barrier in a specific part of the brain to allow drugs to reach just that part.
Israeli scientists at the Ben-Gurion University of the Negev have recently been successful in duplicating a blood-brain barrier outside the patient's body using stem cells and microfluidic chips, producing a functioning copy of a patient's brain structure and thus advancing personalized medicine.
Per-Ola Freskgard to strengthen BioArctic's development of its technology platform to facilitate passage of antibodies and other biologics across the blood-brain barrier.
[USA] Apr 22 (ANI): A recent study claims that obesity can break down the protective blood-brain barrier, which can result in memory loss and learning issues, claim researchers.
10,183,078, relating to a novel approach of using HER3-targeted Eosomes as a shuttle system for transporting various classes of therapeutics across the blood-brain barrier for treatment of brain disorders, including brain cancer.
15, systematically injecting a low dose of a protein called vascular endothelial growth factor temporarily increases the permeability of the blood-brain barrier, a system that blocks about 98 percent of medicines from entering the brain.
This is known as the blood-brain barrier. However, as we age, the blood vessels don't fit as tightly together, which may allow amyloid beta and tau to enter the brain.
Ischemic stroke is a leading cause of death and disability, and the ischemic brain remains a difficult to reach anatomical target because of the blood-brain barrier which limits availability of systemically administered drugs.