blood-brain barrier

(redirected from blood-cerebrospinal fluid barrier)
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blood-brain barrier

(blŭd′brān′)
n.
A physiological mechanism that alters the permeability of brain capillaries, so that some substances, such as certain drugs, are prevented from entering brain tissue, while other substances are allowed to enter freely.

blood′-brain′ bar`rier


n.
a layer of tightly packed cells that make up the walls of brain capillaries and prevent many substances in the blood from diffusing into the brain.
[1940–45]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.blood-brain barrier - a mechanism that creates a barrier between brain tissues and circulating blood; serves to protect the central nervous system; "the brain was protected from the large molecules of the virus by the blood-brain barrier"
barrier - anything serving to maintain separation by obstructing vision or access
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References in periodicals archive ?
The investigators noted that ipilimumab increases antitumor T-cell activation in the lymph nodes, and activated T cells can cross the blood-brain or blood-cerebrospinal fluid barrier.
Topics addressed include the blood-brain barrier in health and neuropathological conditions, targeting the blood-brain barrier for multiple sclerosis therapy, barrier disruptions in stroke, the blood-brain barrier in ischemic stroke, consequences of a disrupted blood-brain barrier to drug delivery, imaging of the blood-brain barrier in acute neurological events, astrocytes and astrocyte- derived factors in the blood-brain barrier in health and diseases, and lipoproteins and apolipoproteins in neurological diseases characterized by blood-cerebrospinal fluid barrier dysfunction.
Isolated blood-cerebrospinal fluid barrier dysfunction: prevalence and associated diseases.