Adolescents who attempt self-harm using bupropion
are at a significantly higher risk of serious morbidity and poor outcomes, compared with those who attempt self-harm with selective serotonin reuptake inhibitors (SSRIs), said Adam Overberg, PharmD, of the Indiana Poison Center in Indianapolis and associates.
The analysis showed that AXS-05 met the prespecified primary endpoint and significantly reduced daily smoking as compared to the active comparator bupropion
. The trial was conducted at the Duke Center for Smoking Cessation under a research collaboration between Axsome and Duke University.
* Participants were randomly assigned to 1 of 3 groups: switching to bupropion
(n = 511), augmenting with bupropion
(n = 506), or augmenting with aripiprazole (n = 505).
* And finally, if the smoker is using a non-nicotine replacement prescription medicine containing bupropion
hydrochloride or varenicline, stay alert to any serious mood or behavior changes or an intent to cause harm.
This agreement allows Orexigen to sell the world-wide rights to Contrave (naltrexone HCl / bupropion
HCl extended release) /Mysimba (naltrexone HCl and bupropion
HCl prolonged release) and certain other Orexigen assets for USD75m in cash.
On the other hand, Bupropion
is an antidepressant that inhibits noradrenaline and dopamine reuptake.
is a preferential norepinephrine and dopamine reuptake inhibitor .
The label for bupropion
(Zyban) will still include a boxed warning, but language describing the potential for serious psychiatric adverse events will no longer appear within it.
Neuropsychiatric adverse events do not increase significantly in smokers treated with either varenicline or bupropion
, a large cohort study shows.
Patients with major depressive disorder (MDD) who have previously failed one or two antidepressant treatments will be treated in an open-label fashion with bupropion
during a 6-week lead-in period.
and Takeda Pharmaceuticals U.S.A., Inc., a wholly-owned subsidiary of Takeda Pharmaceutical Company Limited (TSE:4502) (collectively Takeda), today announced they have agreed to terminate the Amended and Restated Collaboration Agreement for CONTRAVE (naltrexone HCl / bupropion
HCl), the market leading national branded prescription treatment option for certain overweight and obese adults for chronic weight management.
FDA-approved pharmacotherapies The only pharmacotherapies currently approved for use in the treatment of tobacco dependence in nonpregnant adults are nicotine replacement therapies (NRT: transdermal patches, gum, lozenges, nasal spray, or inhalers), bupropion
SR, and varenicline.