Those included were in-patients aged at least 18 years who had no communication problem, were using any of the agents leading to oral mucositis (alkylating agents such as busulfan
, melphalan, cyclophosphamide that are used at high doses; antimetabolites such as methotrexate, 5-fluorouracil; antibiotics such as dactinomycin, adriamycin, bleomycin, and alkaloids such as vinblastine), and who had no oral mucositis and provided informed written consent.
, and/or radiation(XRT)), development of acute GVHD, and CMV reactivation were also considered risk factors for the development of HC.
Patients will undergo a conditioning regimen administration with busulfan
intravenously for four days to achieve myeloablation prior to the transplant.
Finally, the stem cells are infused back into the patient, who has received a low dose of the chemotherapy medication busulfan
to help the genetically corrected stem cells establish themselves in the bone marrow and begin producing new blood cells.
M2 EQUITYBITES-March 18, 2019-Pii partners with Athenex Pharmaceuticals, Sungen Pharma and Chemwerth to manufacture Busulfan
Global Banking News-March 18, 2019-Pii partners with Athenex Pharmaceuticals, Sungen Pharma and Chemwerth to manufacture Busulfan
SunGen Pharma announced the launch of Busulfan
injection, the second product launch through their joint venture Peterson Athenex with Athenex (ATNX).
Hasford score used as prognotic factor in the pre TKI era (busulfan
, interferon), but known to be beneficial as a predicting of TKI therapy response.
We concluded that previous chemotherapy with multiple agents, including high dose busulfan
and cyclophosphamide for stem cell transplant conditioning had led to premature ovarian failure causing her severe climacteric problems.
The most commonly used groups of cytostatics include: --alkylating agents that covalently bind with DNA and RNA forming adducts (cyclophosphamide, ifosfamide, chlorambucil, busulfan
, temozolomide, as well as platinum analogues such as cisplatin, carboplatin and oxaliplatin);
In the pre-engraftment period, diarrhea occurs mostly due to mucosal damage caused by the conditioning regimen, such as alkylating agents, busulfan
, and combination regimens or radiotherapy (7).
Food and Drug Administration has approved use of Busulfan
Injection, the company's therapeutic equivalent for Busulfex.