TNF

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Related to cachectin: tumor necrosis factor, TNF alpha

TNF

abbr.
tumor necrosis factor
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.TNF - a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
cytokine - any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system
References in periodicals archive ?
Barral et al., "Tumor necrosis factor (cachectin) in human visceral leishmaniasis," The Journal of Infectious Diseases, vol.
Mast cell as a source of both preformed and immunologically inducible TNF-ct/ cachectin. Nature 1990; 346 : 274-6.
TNF alone20 or in combination with other cytokines such as IL1, and IL6, have been shown to be involved in protein wasting and loss of nitrogen associated with cachectin situations.
Shock and tissue injury induced by recombinant human cachectin. Science 1986; 234(4775):470-4.
The researchers applied cachectin, with is produced by ifnection-fighting white blood cells, to mature fat cells and found that the cells lost their fat-synthesizing and storage potential.