Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.


Weight loss, wasting of muscle, loss of appetite, and general debility that can occur during a chronic disease.

[Late Latin, from Greek kakhexiā : kako-, caco- + hexis, condition (from ekhein, to have; see segh- in Indo-European roots).]


(kəˈkɛksɪə) or


(Pathology) a generally weakened condition of body or mind resulting from any debilitating chronic disease
[C16: from Late Latin from Greek kakhexia, from kakos bad + hexis condition, habit]
cachectic, cachectical, cachexic adj


(kəˈkɛk si ə)

also ca•chex•y


general ill health with emaciation, usu. occurring in association with a disease.
[1535–45; < Late Latin < Greek, =kak(ós) bad + héx(is) condition]
ca•chec′tic (-tɪk) adj.

cachexia, cachexy

general physical or mental poor health; weakness or malnutrition.
See also: Health
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cachexia - any general reduction in vitality and strength of body and mind resulting from a debilitating chronic disease
debility, feebleness, frailness, frailty, infirmity, valetudinarianism - the state of being weak in health or body (especially from old age)


n. caquexia, condición grave que se caracteriza por pérdida excesiva de peso y debilidad general progresiva.
References in classic literature ?
rheums, cachexia, bradypepsia, bad eyes, stone, and collick,
Cachexia is a prevalent pathological condition associated with chronic heart failure.
M2 PHARMA-June 7, 2017-Innovus Pharma Gains Exclusive License to OTC Compounds for Cachexia and Muscle Growth from the University of Iowa Research Foundation
In conjunction, the company has started the review of international medical facilities to commence preclinical and clinical trials in support of the patent portfolio, which includes IGC-501 for neuropathic pain, IGC-502 for the treatment of seizures and IGC-504 for eating disorders, including cachexia.
Pooled, post-hoc efficacy data analysis from the ROMANA 1 and ROMANA 2 Phase III studies demonstrates that in NSCLC patients with cachexia and a low BMI, anamorelin significantly improves fatigue in addition to symptom burden (including appetite) and increases lean body mass and fat.
USPRwire, Wed Mar 09 2016] GlobalData's clinical trial report, "Cachexia Global Clinical Trials Review, H1, 2016" provides an overview of Cachexia clinical trials scenario.
Approximately, 50% of patients with advanced stage of cancer experience cachexia and more than the third die following the loss of ~75% of skeletal muscle mass [1].
It also reviews key players involved in the therapeutic development for Cachexia and special features on late-stage and discontinued projects.
Cancer cachexia is a feature of advanced cancer characterised by anorexia and a progressive loss of body weight, reduced immune response, poor treatment response, and poor quality of life.
In this study, the cancer cachexia model was established by subcutaneous transplantation CT26 tumor fragment.
First-in-Class Anabolic Catabolic Transforming Agent Holds Promise in Treating Cancer Cachexia, Age-Related Sarcopenia
60), (61) Cancer cachexia is induced by many factors, the most prominent of which is decreased tissue carnitine levels.