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Weight loss, wasting of muscle, loss of appetite, and general debility that can occur during a chronic disease.

[Late Latin, from Greek kakhexiā : kako-, caco- + hexis, condition (from ekhein, to have; see segh- in Indo-European roots).]


(kəˈkɛksɪə) or


(Pathology) a generally weakened condition of body or mind resulting from any debilitating chronic disease
[C16: from Late Latin from Greek kakhexia, from kakos bad + hexis condition, habit]
cachectic, cachectical, cachexic adj


(kəˈkɛk si ə)

also ca•chex•y


general ill health with emaciation, usu. occurring in association with a disease.
[1535–45; < Late Latin < Greek, =kak(ós) bad + héx(is) condition]
ca•chec′tic (-tɪk) adj.

cachexia, cachexy

general physical or mental poor health; weakness or malnutrition.
See also: Health
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cachexia - any general reduction in vitality and strength of body and mind resulting from a debilitating chronic disease
debility, feebleness, frailness, frailty, infirmity, valetudinarianism - the state of being weak in health or body (especially from old age)


n. caquexia, condición grave que se caracteriza por pérdida excesiva de peso y debilidad general progresiva.
References in classic literature ?
rheums, cachexia, bradypepsia, bad eyes, stone, and collick,
formed a collaboration to discover and develop selective androgen receptor modulators, or SARMs, a new class of drugs with the potential to treat sarcopenia, which is the loss of skeletal muscle mass resulting in reduced physical strength and ability to perform activities of daily living, as well as cancer cachexia (cancer induced muscle loss) and other musculoskeletal wasting conditions.
DeBakey Veterans Affairs Medical Center, in Houston, Texas, has initiated a Phase 2A trial assessing the safety and efficacy of repeated doses of the Company's ghrelin agonist, AEZS-130 (macimorelin), in patients with cancer cachexia.
and much of the rest of the world, there are no approved treatments for cancer-related cachexia even though it affects a majority of cancer patients, including up to sixty percent* of those with lung cancer," commented Dr.
NASDAQ: GTXI), today announced that results of the Phase II clinical trial evaluating Ostarine[TM] (MK-2866) for the treatment of cancer cachexia will be presented at ENDO 2009, The Endocrine Society's Annual Meeting, being held in Washington, DC June 10-13 at the Walter E.
So in the model of cachexia inducing by CT26 tumor, the dosages of parthenolide was determined as 5 and 25 mg/kg/d and its effect was researched.
First-in-Class Anabolic Catabolic Transforming Agent Holds Promise in Treating Cancer Cachexia, Age-Related Sarcopenia
New research shows that a molecule called pateamine A can interfere with the biochemical pathways that cause cachexia, and may point the way toward a therapy.
Cancer cachexia affects between 50% and 80% of cancer patients, according to Nagi B.
Most birds presented for necropsy had lesions attributed to predation or human-related trauma; however, several budgerigars had marked cachexia (Fig la), hepatomegaly (Fig 1b) and splenomegaly (Fig 1c and d).
Before now, cachexia, characterized by muscle wasting and dramatic weight loss, was believed to spare the heart.
Later, 2 isolated sick chamois found in May and October had mainly clinical signs of cachexia and alopecia, similar to those previously observed in 2001 and 2002 (1).