calcitriol


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cal·ci·tri·ol

 (kăl′sĭ-trī′ôl′, -ōl′)
n.
The active metabolite of vitamin D, C27H44O3, that is synthesized in the kidneys and liver from vitamin D2 or vitamin D3 and acts as a calcium-regulating hormone. A synthetic form is used as a drug to treat hypocalcemia, bone disease caused by renal failure, and, in topical preparations, psoriasis.

Translations

calcitriol

n calcitriol m
References in periodicals archive ?
Mutations in CYP27B1 lead to a loss of 1[alpha]-hydroxylase activity and require treatment with calcitriol to normalize the clinical and laboratory abnormalities (15).
The main adaptation through which women meet the calcium demands of pregnancy is by the doubling of their intestinal calcium absorption driven by calcitriol and other factors as early as 12 weeks gestation.
"The active form of Vitamin D -- calcitriol -- not just controls the oestrogen content in a woman, but many other genes that are involved in embryo implantation," explained Dr Nazareth.
Goals for treatment involve a serum 25-hydroxyvitamin D concentration >30 ng/mL (75 nmol/L) and normalization of the serum parathyroid hormone, which may even require the use of calcitriol (2).
Calcitriol, the active metabolite of vitamin D3, can bind to both the VDR and retinoid X receptor (RXR) in sequence to form a heterodimer [5, 6].
Pertinent medications included calcium carbonate, vitamin D3, calcitriol, atripla (efavirenz/emtricitabine/tenofovir disoproxil), hydrochlorothiazide, and inhaled budesonide/formoterol.
Five out of eight cases were on a less than daily dosing of calcitriol and four out of eight cases had low levels of vitamin D.
Research shows that lack of calcium in the body can trigger the release of calcitriol, a hormone that could cause fat storage in the body.
Transcriptional effects however, were not reproducible in post-menopausal breast cancer patients and the genomic pathway was not induced in tumor specimens collected after a short period of calcitriol supplementation (0.5[micro]g/PO/day for 30 days) (Urata et al., 2014).
During CKD, patients display dysfunctional mineral metabolism, displaying decreased conversion of vitamin D to its active form 1,25-dihydroxyvitamin D (or calcitriol), increased expression of PTH (secondary hyperparathyroidism), and decreased expression of klotho.
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