Calchan Ltd is developing its own portfolio of calcium ion
channel modulators and has two Phase II clinical studies in progress in post-herpetic neuralgia and painful diabetic neuropathy.
The calcium ion
is required for the operation of a number of physiological processes, such as bone and tooth formation, blood coagulation, nerve impulse transmission, and muscle contraction.
The phenomenon is well known for calcium; pH influences the serum concentration of free calcium ion
The resulting calcium ion
overload in the cell leads to its death and skin exfoliation.
measurements currently comprise more than 1/3 of all ion channel screens and more than 1/2 of all of G protein receptor (GPCR) screens.
Now one camera covers a wide range of imaging needs-including super resolution microscopy, TIRF microscopy, live cell GFP, high-speed calcium ion
imaging, FRET, real-time confocal microscopy, and many more.
The particles have been surface modified with proteins that will induce particle aggregation in response to elevated intracellular calcium ion
levels that accompany synaptic activation and action potential firing.
We also validated that boosting extracellular calcium ion
levels boosts seizure and migraine risk by 1) depolarizing nerve membranes, 2) increasing calcium channel mediated neurotransmitter release and 3) boosting muscle contractility," according to Mark Zamoyski, NexGen Biomedical, Inc.
Verapamil is the generic equivalent of Lederle Laboratories' Verelan(R), calcium ion
influx inhibitor (slow channel blocker or calcium ion
antagonist), which is indicated for the management of essential hypertension.
Stabilizing the bone microenvironment to prevent the calcium ion
spike can be accomplished by repurposing drugs used for treatment of osteoporosis or management of hypercalcemia,"Mr.
SERCA2a is a calcium ion
pump found in heart tissue.
flux, pH changes, cAMP levels and other signals) to test compounds and can perform all three levels of compound characterization: functional screening, affinity profiling and selectivity profiling -- all in a high-throughput format.