calpain


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Related to calpain: cathepsin, calpastatin

cal·pain

 (kăl′pān′)
n.
A proteolytic enzyme regulated by the concentration of calcium ions.

[Probably cal(cium) + p(rote)a(se) + -in.]

calpain

(ˈkælpeɪn)
n
any of various enzymes in mammals and other organisms that are involved in the proteolysis of endogenous proteins and are regulated by the concentration of calcium ions
[C20: from cal(modulin) + (pa)pain]
References in periodicals archive ?
Calpain and cathepsin activities in postmortem fish and meat muscles.
- South San Francisco, California-based anti-fibrotic therapies specialist Blade Therapeuticshas initiated a Phase 1 clinical trial for its lead compound, BLD-2660, a selective small molecule dimeric calpain inhibitor, the company said.
By generating potent inhibitors to Calpain, Phelix is able to block the generation of myofibroblasts, the critical cell type in fibrosis.
Eklund, "Bcr-abl regulates Stat 5 through Shp2, the interferon consensus sequence binding protein (Icsbp/Irf8), growth arrest specific 2 (Gas2) and calpain," Oncotarget, vol.
Greer, "Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis," The Journal of Biological Chemistry, vol.
Long-lasting Ca2+ elevations activate calpain proteases, which further degrade proteins that participate in Ca2+ homeostasis and thereby aggravate myoplasmic Ca2+ overload.
Ishiguro, "[Ca.sup.2+]-induced release of mitochondrial m-calpain from outer membrane with binding of calpain small subunit and Grp75," Archives of Biochemistry and Biophysics, vol.