It reveals calpain
could be a target for new drugs.
Immature rats were compared with adolescent and mature rats for GABA-A alpha 1 level and calpain
and cathepsin activities in postmortem fish and meat muscles.
- South San Francisco, California-based anti-fibrotic therapies specialist Blade Therapeuticshas initiated a Phase 1 clinical trial for its lead compound, BLD-2660, a selective small molecule dimeric calpain
inhibitor, the company said.
By generating potent inhibitors to Calpain
, Phelix is able to block the generation of myofibroblasts, the critical cell type in fibrosis.
Polymorphism of calpastatin, calpain
and myostatin genes in native Dalagh sheep in Iran.
Eklund, "Bcr-abl regulates Stat 5 through Shp2, the interferon consensus sequence binding protein (Icsbp/Irf8), growth arrest specific 2 (Gas2) and calpain
," Oncotarget, vol.
Greer, "Ubiquitous calpains
promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis," The Journal of Biological Chemistry, vol.
Long-lasting Ca2+ elevations activate calpain
proteases, which further degrade proteins that participate in Ca2+ homeostasis and thereby aggravate myoplasmic Ca2+ overload.
Ishiguro, "[Ca.sup.2+]-induced release of mitochondrial m-calpain from outer membrane with binding of calpain
small subunit and Grp75," Archives of Biochemistry and Biophysics, vol.