cantharidin


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can·thar·i·din

 (kăn-thăr′ĭ-dĭn)
n.
A toxic compound, C10H12O4, that is found in blister beetles and is the active ingredient of Spanish fly.

cantharidin

(ˌkænˈθærɪdɪn)
n
the compound C10H12O4, which is the active ingredient in cantharides and is secreted by many species of blister beetle
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COVE-1 included two cohorts that evaluated the safety and efficacy of VP-102, a novel topical therapy containing a solution of 0.7% cantharidin in a proprietary single-use applicator, in subjects with up to six warts.
Cantharidin exerts anti-hepatocellular carcinoma by miR-214 modulating macrophage polarization.
Treatment satisfaction was high, with 94% of caregivers saying they would request cantharidin again if molluscum contagiosum were to recur on the child's face, and 92% saying they would recommend it to others.
So while pediatric dermatologists still do "small procedures" every hour in most practices (cryotherapy for warts, cantharidin for molluscum, shave and punch biopsies), a subset now has extensive procedural practices, which in recent years has extended to pigment lesion lasers (to treat nevus of Ota), hair lasers (to treat perineal areas to prevent pilonidal cyst recurrence or to treat hirsutism), and combinations of lasers (to treat hypertrophic, constrictive, and /or deforming scars).
While cantharidin causes some side effects such as hematochezia and tenesmus, it can efficiently inhibit various tumor cell lines, we must attach importance to it.
(1,11,12,13,14) Silver nitrate, phenol, and trichloracetic acid are used as chemical agents, while treatment options for immunocompromised patients with refractory lesions include topical cidofovir (5%), intralesional or systemic interferon, imiquimod cream (5%), salicylic acid, glycolic acid, tretinoin, tazarotene, 5% sodium nitrate, podophyllotoxin, liquefied phenol, cantharidin, potassium hydroxide, 1% adenine cream, and oral cimetidine.
Active ingredient Lipid-based formulation Vinorelbine Gypenoside Liposomes Curcumin 3-EGCG Brucine Quercetin Kaempferol Isorhamnetin Phytosome Silybin 3-EGCG Quercetin [beta]-Elemene Hydroxysafflor yellow A Microemulsions Puerarin Baicalin SEDS Curcumin Indirubin Hydroxysafflor yellow A Gentiopicrin Lutein Apigenin Nobiletin SMEDS Oridonin Silymarin Puerarin Hesperidin Berberine hydrochloride (BBH) Morin Curcumin Lutein SNEDS Oleanolic acid Vinpocetine Puerarin Triptolide SLNs Cantharidin Resveratrol Silymarin Tripterine NLCs Curcumin Active ingredient Effect of formulation Vinorelbine Reduced side effects and increased circulation half-life.
The major component of MP, cantharidin, also has anticancer and apoptotic effects on cancer cells [10].