Nibin was admitted with flu-like symptoms after suffering adverse effects from a drug called Carbamazepine
The following combined two groups of keywords were used: (lupus, systemic lupus erythematosus, SLE, lupus-like, SLE-like, drug induced lupus) and (carbamazepine
, Tegretol, anticonvulsant).
Hepatoxicity, Portal hypertension, Oesophageal varices carbamazepine
Its chemical structure is similar to carbamazepine
and both have similar mechanisms of action (2).
In her detailed history, it was learned that the patient had used valproic acid in the last six months and carbamazepine
was added to treatment one month ago because her seizures could not be controlled.
Thus, the present work aimed to develop and apply a method based on the solid-phase extraction of caffeine, atrazine, and carbamazepine
followed by the quantification by ultra-efficiency liquid chromatography coupled to a high-resolution hybrid mass spectrometer (quadrupole-time-of-flight).
This study did not discuss HLA association with other cADRs associated with carbamazepine
. The Food and Drug Administration (FDA) of the USA and the Clinical Pharmacogenetics Implementation Consortium (CPIC) have recommended screening for the HLA-B * 15:02 allele prior to initiating treatment with carbamazepine
in patients with Asian ancestry [13, 14].
Each group comprised of 100 subjects labeled as Group-A (control group had healthy individuals), Group-B (newly diagnosed epileptic patients without antiepileptic therapy), Group-C (epileptic patients on Carbamazepine
therapy, which was further subdivided into C-I having epileptic patients on Carbamazepine
therapy less than 1 year n=33, C-II had epileptic patients on Carbamazepine
therapy 1-2 years n = 33 and C-III comprised of epileptic patients on Carbamazepine
therapy more than 2 years n = 34).
The research team discovered in lab and mouse studies that the drug carbamazepine
, already approved for treating conditions such as epilepsy and bi-polar disease, can significantly reduce the effects of MCDS.
proved to be the most notorious (29.6%) followed by lamotrigine (9.3%).
 SJS is usually associated with anticonvulsants including carbamazepine
, lamotrigine, phenobarbital, phenytoin and valproic acid.
* Aromatic: phenobarbital, Phenytoin, carbamazepine