announced results from a Phase 2, randomized, placebo-controlled trial evaluating two doses of GS-0976, an oral, investigational inhibitor of Acetyl-CoA carboxylase
, in patients with nonalcoholic steatohepatitis.
Many animals can convert extra tryptophan (an amino acid) to niacin, but cats have large amounts of the enzyme picolinic acid carboxylase
that interferes with the conversion.
Genes that have been traditionally sequenced for identification of plants include ribulose-1, 5-biphosphate carboxylase
(rbcL), and maturase K (matK).
Keywords: Hypoxic-ischemic encephalopathy, Molybdenum cofactor deficiency, Pyruvate carboxylase
deficiency, Zellweger syndrome, Non-ketotichyperglycinaemia.
PA is a rare, life-threatening, inherited metabolic disorder due to a defect in the mitochondrial enzyme propionyl-CoA carboxylase
, or PCC.
A separate Phase 2 study (ATLAS) is investigating treatment with GS-9674, the investigational apoptosis signal-regulating kinase 1 (ASK-1) inhibitor selonsertib, and the investigational acetyl-CoA carboxylase
inhibitor GS-0976 alone or in combination, in patients with advanced fibrosis due to NASH.
In addition, adiponectin inhibits gluconeogenesis by phosphorylating AMPK and acetyl-CoA carboxylase
(24) Acetyl coenzyme A carboxylase
(ACC) catalyzes the rate-limiting step in synthesis of fatty acids that become components of sebaceous lipids.
Enzyme defects indicated by solid bars are numbered as follows: (1), branched-chain 2-ketoacid dehydrogenase complex deficiency (MSUD, maple syrup urine disease); (2), isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia); (3), isolated 3-methylcrotonyl-CoA carboxylase
deficiency; (4), 3-methylcrotonyl-CoA carboxylase
deficiency as part of a multiple carboxylase
deficiency due to nutritional biotin deficiency or biotinidase deficiency or holocarboxylase synthetase deficiency or carbonic anhydrase VA deficiency or MT-ATP6 deficiency; (5), 3-methylglutaconyl-CoA hydratase deficiency; (6), 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase deficiency.
* DRM01, a topical sebum inhibitor that inhibits acetyl coenzyme-A carboxylase
, an enzyme involved in the synthesis of fatty acids.
The protein spots 702, 528, 635, 661, and 1,299 modulated upon infestation with red palm weevil are related to photosynthetic machinery and identified as ribulose bisphosphate carboxylase
"High dose biotin seems to be driving the fatty acid synthesis, and with fatty acid synthesis there is signaling that goes on with the ACC (Acetyl CoA Carboxylase