(UCS) is a rare uterine neoplasm, with an incidence of 3%-4% among all uterine malignancies (1).
The patient was eventually diagnosed with a carcinosarcoma
, which was classified as IVB (T3N2M0) per the 8th American Joint Committee on Cancer Tumor-Node-Metastasis staging system.
World Health Organization Classification of Malignant Odontogenic Tumors Descriptor ICD-O Codes (a) Ameloblastic carcinoma 9270/3 Primary intraosseous carcinoma, NOS 9270/3 Sclerosing odontogenic carcinoma 9270/3 Clear cell odontogenic carcinoma 9341/3 Ghost cell odontogenic carcinoma 9302/3 Odontogenic carcinosarcoma
8980/3 Odontogenic sarcomas 9330/3 Abbreviation: NOS, not otherwise specified.
(1) It is characterized by the histologic combination of malignant teratoma and carcinosarcoma
with a triphasic growth pattern including epithelial, mesenchymal and primitive neuroectodermal components (2), and it mainly occurs in the nasal cavity and paranasal sinuses, although tumours occurring at other locations like nasopharynx and oral cavity have also been described.
Histologic types of serous and carcinosarcoma
of the endometrium cancers are less common than endometrioid histology and have a worse prognosis.
Cases of non-primary bladder cancer (direct extension of adenocarcinoma of the rectum in 1 patient), non-urothelial bladder cancers (carcinosarcoma
in 1 patient and fibrosarcoma in 1 patient) and non-malignant bladder conditions (emphysematous cystitis in 1 patient and eosinophilic cystitis in 1 patient) were excluded.
Therefore, endometrial neoplasms involving giant cells were considered and differential diagnosis included carcinoma, carcinosarcoma
, leiomyosarcoma with osteoclast-like giant cells, undifferentiated sarcoma and choriocarcinoma with osteoclast-like giant cells.
Invasive Ductal Carcinoma with Chondromyxoid Sarcoma or Carcinosarcoma
([paragraph]) Uterine cancers were classified by histologic type (endometrioid carcinoma, other carcinoma, carcinosarcoma
, and sarcoma).
To the Editor: A uterine carcinosarcoma
(malignant mixed Mullerian tumor [MMMT]) is a rare, aggressive, malignant tumor which demonstrates both malignant epithelial (carcinoma) and mesenchymal (sarcoma) components. MMMTs account for 2-5% of all uterine malignancies.
According to World Health Organization histological classification (2005), 'malignant mixed tumors,' should be divided into three different clinical and histological entities: CaExPA, carcinosarcoma
(true malignant mixed tumors), and metastasizing PA.
MMMT also termed as carcinosarcoma
is a highly malignant neoplasm, exhibiting malignant epithelial and stromal components.