Subtypes of endometrial cancer include the more common type I, endometrioid adenocarcinoma, and the rare type II, which encompasses clear-cell, carcinosarcomas
, and endometrial serous carcinoma.
Vimentin, on the other hand, shows negativity in UC, and in fact, this may be used to differentiate UC from vimentin-positive carcinosarcomas
with rhabdoid features.
Sarcomas and carcinosarcomas
of the uterine cervix.
Pelvic chondrosarcomas can appear in various pathologic neoplasms, other than pure chondrosarcoma arising from the pelvic bone, such as chondrogenic tumors of the ovaries or heterologous carcinosarcomas
of the uterus.
Due to the heterogeneity of the tumour, obtaining a tissue diagnosis of carcinosarcomas
is difficult as a needle biopsy would often just reflect one element of the tumour.
The malignant lesions of endomyometrium are various endometrial adenocarcinomas, stromal sarcomas, leiomyosarcomas and carcinosarcomas
They include serous, clear cell, mucinous, squamous, transitional cell, carcinosarcomas
and undifferentiated tumors.
La presentacion clinica de los carcinosarcomas
uterinos es similar a la de los adenocarcinomas de endometrio, generalmente se manifiesta con metrorragia posmenopausica o masas uterinas que en muchos casos protruyen por el orificio cervical externo (2).
Recent research has highlighted the antitumor and anti-cancer effects of WEL, like inhibiting the growth of pituitary adenoma cells and mammary carcinosarcomas
in vitro [51,23]; suppress cellular growth and to induce apoptosis of androgen receptor-negative MDA-MB-231 breast cancer cells, and also growth suppressor independently of NFB and androgen receptors .
For example, significant differences have been noted in the frequencies of mutations among the ARID1A, PTEN, PIK3CA, PPP2R1A (protein phosphatase 2, regulatory subunit A, alpha), TP53, and CTNNB1 genes in low-grade endometrioid endometrial carcinoma, high-grade endometrioid endometrial carcinoma, serous endometrial carcinoma, and endometrial carcinosarcomas
, and the pattern of mutations in this 6-gene set has facilitated the histologic reclassification of some endometrial tumors (58).
Specifically, black patients were rarely diagnosed with Grades 1-2 endometrioid cancers (5% vs 9% for Grade 3 endometrioid cancers; 20% for serous cancers, 23% for carcinosarcomas
, and 12% for clear-cell cancers).
Sinonasal teratocarcinosarcoma (SNTCS) is an extremely rare malignancy of the paranasal sinuses that possesses the histopathologic features of both teratomas and carcinosarcomas