[17,20] The hallmark of CCB OD is therefore circulatory shock due to bradycardia, poor cardiac contractility
and profound peripheral vasodilatation.
For instance, modulation of cardiac contractility
as a therapy for heart failure, modulation of gastric contractility as a therapy for diabetes, and modulation of vagus nerve traffic as a therapy for epilepsy and inflammatory diseases.
MYK-491, MyoKardia's second product candidate, is designed to increase cardiac output among patients with systolic heart dysfunction by increasing the overall extent of the heart's cardiac contractility
. MyoKardia is currently evaluating MYK-491 in a Phase 1b/2a study in stable heart failure patients.
Cytokinetics, Incorporated announced that preclinical data for CK-3773274 were presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions in Boston, showing that CK-274 decreased cardiac contractility
in vitro, in vivo in healthy animals, and in vivo in a mouse model of hypertrophic cardiomyopathy (HCM).
According to the company, the Optimizer Smart System is the first and only CCM (Cardiac Contractility
Modulation) device approved by the US FDA to improve six-minute hall walk distance, quality of life and functional status of NYHA Class III heart failure patients, who are not indicated for CRT and have an LVEF ranging from 25% to 45%.
Effect of tidal volume, intrathoracic pressure, and cardiac contractility
on variations in pulse pressure, stroke volume, and intrathoracic blood volume.
This research reported for the first time that acute chemerin treatment of isolated perfused rat leads to decreases in cardiac contractility
. In addition, in this work, the negative inotropic effects of chemerin were antagonized with L-NAME.
A new type of treatment called cardiac contractility
modulation (CCM) appears to improve heart function in heart-failure patients with few other options.
Indeed, arterial pressure determinant analysis with the well-known equation Arterial Pressure=Cardiac Output x Systemic Vascular Resistance, shows that the arterial pressure decrease observed in this setting could be theoretically due to an impairment in cardiac contractility
. As they are load dependent, usual left ventricular (LV) systolic function parameters, such as LV ejection fraction (LVEF), are inefficient for exploring myocardial effects of SA.
Thyrotoxicosis affects the cardiovascular system via [T.sub.3]-mediated effects by increasing cardiac contractility
, enhancing systolic and diastolic function, decreasing systemic vascular resistance and increasing circulating blood volume leading to increased preload, decreased afterload, and therefore increasing cardiac output by up to 300% from a euthyroid state .
Tension PPC inhibits cardiac contractility
and venous return to the heart, resulting in decreased cardiac output.
Subclinical hypothyroidism increases isovolumetric relaxation time, decreases endothelial relaxation, and decreases cardiac contractility