Indeed, drugs such as paclitaxel, etoposide, methotrexate, and carmustine
associated to LDE had the ability to markedly reduce the lesions and the concurrent proliferative and inflammatory processes (24).
High-dose cyclophosphamide, carmustine
, and etoposide followed by allogeneic bone marrow transplantation in patients with lymphoid malignancies who had received prior dose-limiting radiation therapy.
Knopp et al., "Pattern of recurrence following local chemotherapy with biodegradable carmustine
(BCNU) implants in patients with glioblastoma," Journal of Neuro-Oncology, vol.
Meanwhile the patient underwent carmustine
therapy on the suspicion of mycosis fungoides without any apparent clinical effect.
Prior to 1999, nitrosourea-based combinations were the most commonly used chemotherapeutic agents in GBM, among which carmustine
and lomustine were the most active agents.
In the conventional melanoma chemotherapy treatment, antineoplastic agents have been a principal tool for combating cancer , specifically dacarbazine, temozolomide, carmustine
, lomustine, vincristine, vinblastine, cisplatin, carboplatin, taxol, docetaxel, and so forth [11, 12].
Braunsdorf et al., "The combination of carmustine
wafers and temozolomide for the treatment of malignant gliomas.
Kowalczyk et al., "Combination therapy with AKT3 and PI3KCA siRNA enhances the antitumor effect of temozolomide and carmustine
in T98G glioblastomamultiforme cells," BioDrugs, vol.
Bortey et al., "A phase 3 trial of local chemotherapy with biodegradable carmustine
(BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma," Neuro-Oncology, vol.
Glutathione released into the cell culture medium was also quantitated enzymatically after 4 h in cystine-free medium and normalized to total cellular protein; 1,3-bis[2-chloroethyl]-2-nitrosourea (BCNU; Carmustine
) was solubilized in ethanol, which was also used as the vehicle control.
Michalak et al., "Phase III trial of carmustine
and cisplatin compared with carmustine
alone and standard radiation therapy or accelerated radiation therapy in patients with glioblastoma multiforme: North Central Cancer Treatment Group 93-72-52 and Southwest Oncology Group 9503 Trials," Journal of Clinical Oncology, vol.