carmustine


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Related to carmustine: lomustine, BiCNU, Mechlorethamine

car·mus·tine

 (kär′mŭs-tēn′)
n.
An antineoplastic drug, C5H9Cl2N3O2, used to treat various malignancies, including Hodgkin and non-Hodgkin lymphomas, melanoma, multiple myeloma, and brain tumors.

[Probably car(bamoylation), transfer of a carbamoyl group to an amino acid (the drug's method of inhibiting certain enzymes) + mustine, an anticancer drug (must(ard) + -ine).]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Indeed, drugs such as paclitaxel, etoposide, methotrexate, and carmustine associated to LDE had the ability to markedly reduce the lesions and the concurrent proliferative and inflammatory processes (24).
High-dose cyclophosphamide, carmustine, and etoposide followed by allogeneic bone marrow transplantation in patients with lymphoid malignancies who had received prior dose-limiting radiation therapy.
Knopp et al., "Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in patients with glioblastoma," Journal of Neuro-Oncology, vol.
Meanwhile the patient underwent carmustine therapy on the suspicion of mycosis fungoides without any apparent clinical effect.
Prior to 1999, nitrosourea-based combinations were the most commonly used chemotherapeutic agents in GBM, among which carmustine and lomustine were the most active agents.
In the conventional melanoma chemotherapy treatment, antineoplastic agents have been a principal tool for combating cancer [10], specifically dacarbazine, temozolomide, carmustine, lomustine, vincristine, vinblastine, cisplatin, carboplatin, taxol, docetaxel, and so forth [11, 12].
Braunsdorf et al., "The combination of carmustine wafers and temozolomide for the treatment of malignant gliomas.
Kowalczyk et al., "Combination therapy with AKT3 and PI3KCA siRNA enhances the antitumor effect of temozolomide and carmustine in T98G glioblastomamultiforme cells," BioDrugs, vol.
Bortey et al., "A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma," Neuro-Oncology, vol.
Glutathione released into the cell culture medium was also quantitated enzymatically after 4 h in cystine-free medium and normalized to total cellular protein; 1,3-bis[2-chloroethyl]-2-nitrosourea (BCNU; Carmustine) was solubilized in ethanol, which was also used as the vehicle control.
Michalak et al., "Phase III trial of carmustine and cisplatin compared with carmustine alone and standard radiation therapy or accelerated radiation therapy in patients with glioblastoma multiforme: North Central Cancer Treatment Group 93-72-52 and Southwest Oncology Group 9503 Trials," Journal of Clinical Oncology, vol.