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Related to caseation: tuberculosis, caseation necrosis


Necrotic degeneration of bodily tissue into a soft, cheeselike substance.

[From Latin cāseus, cheese.]


1. (Biochemistry) the formation of cheese from casein during the coagulation of milk
2. (Pathology) pathol the degeneration of dead tissue into a soft cheeselike mass


(ˌkeɪ siˈeɪ ʃən)

1. transformation of tissue into a soft cheeselike mass, as in tuberculosis.
2. the formation of cheese from casein during the coagulation of milk.


the change in consistency of tissue to a soft, cheeselike form, as in tuberculosis.
See also: Body, Human, Disease and Illness
the formation of cheese from casein during the coagulation of milk.
See also: Cheese
References in periodicals archive ?
Caseous necrosis with epithelioid granulomas was observed in 47 cases and granulomas without caseation was observed in 27 cases.
Mycobacterium tuberculosis cultures assisted in definitive decision-making but granulomatous inflammation could not be anticipated when the specimens were initially processed except when visible caseation was encountered.
Instead, a considerable number of ITB cases had biopsies with features of chronic inflammation or granulomas without caseation, a finding consistent with other reports.
Microscopic examination showed numerous epithelioid cell granulomas with Langhans giant cells and large areas of caseation necrosis in the pancreas.
Cases of caseating epithelioid granulomatous pattern can be wrongly labeled as necrotizing lymphadenitis pattern if material is aspirated from that part of the node that contains only caseation.
Diagnosis of tuberculosis was confirmed on finding typical granulomas comprising of lymphocytes, Langhans type giant cells with or without caseation.
Contrast enhanced CT scan (CECT) of neck showed multiple lymph nodes at level IV on the right side and in the right supraclavicular region showing peripheral rim enhancement with central caseation necrosis (Figures 4, 5, and 6).
It has been suggested that this colonisation is followed by the destruction of the alveolar epithelium, granuloma formation and subsequent caseation and liquefaction of the granulomatous tissue [9].
The histologic hallmark of hepatic tuberculosis is the epithelioid granuloma, often with caseation and giant cells (Figure 2, A).
Upper dermis shows tuberculoid granulomas consisting of epithelioid cells and multinucle- ated giant cells mainly of Langhans type with sparse or no central caseation within the tuber- cle9 along with abundant lymphocytic infiltra- tion.
22,23) TBRM is characterized by a gross granulomatous reaction with associated histiocytic proliferation, caseation and tubercle formation that expands and fills the space between the spinal dura mater and the leptomeninges.
TB bacilli cause caseation necrosis in the intestine followed by spread to the mesenteric lymph nodes that may rupture into the peritoneum causing TB peritonitis4.