Pathological examination of the left helix showed that the epidermis was thin, with flattening of the rete ridges and many epithelioid granulomas with local caseous necrosis
, accompanied by infiltration of lymphocytes into the dermis, multinucleated giant cells were not remarkable [Figure 1]b.
8] In general, tuberculous (TB) lymphadenitis is diagnosed using conventional methods such as histopathology on the basis of caseous necrosis
and granuloma formation.
Pathological examination revealed granuloma structures with caseous necrosis
composed of epithelioid histiocytes.
Patients with suggestive symptoms and signs, consistent radiological findings and caseous necrosis
, those having positive AFB stain or MTB cultures were clinically deemed to be TB.
Caption: Figure 1: Lymph node biopsy showing caseous necrosis
, Langhans giant cells, and epithelioid cells
9-12) The specific histopathological features of leprous neuritis include the presence of AFB and caseous necrosis
Isolated peripancreatic lymph nodes also showed epithelioid cell granulomas with caseous necrosis
Diagnosis is usually confirmed by finding acid fast bacilli (AFB) and positive AFB cultures of bone (positive in up to 75% of cases), and caseous necrosis
and granuloma on histopathology (11).
Granulomatous inflammation is a distinct form of chronic inflammation characterized by collection of epithelioid cells, giant cells and surrounded by mononuclear cells with or without caseous necrosis
2) The pathologic hallmark of sarcoidosis is the presence of granulomatous inflammation without central caseous necrosis
Histologically, the granulomas in all tissues examined demonstrated similar histopathologic features, characterized by a central core of caseous necrosis
and surrounded by an unorganized rim of mixed inflammatory cells, including neutrophils, lymphocytes, plasma cells, and epithelioid macrophages.
Disseminated histiocytic infiltration of either aggregates or sheets of epithelioid cells containing acid-fast bacilli, in the absence of caseous necrosis
, were observed in different organs of the infected doves, especially lungs (23/23), intestines (9/23).