caspase


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Related to caspase: Caspase 3, Caspase 9

caspase

(ˈkæspeɪz)
n
a type of enzyme that is involved in apoptosis and necrosis
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.caspase - any of a group of proteases that mediate apoptosis
peptidase, protease, proteinase, proteolytic enzyme - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Treatment with TNF-[alpha] alone significantly increased the expression of cleaved caspase 3 (Figure 5C).
However, it can also act as an independent caspase and both (caspase-8 and 10) can function independently without depending on each other.
Kondo et al., "Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from parkinsonian brain," Journal of Neural Transmission, vol.
Caspases are proteolytic enzymes that can cause cell death by apoptosis, necrosis, and inflammation.
Currently most anti-cancer therapies (chemotherapy, radiation and immunotherapy) work by killing cancer cells through a process called apoptosis, which activates proteins called caspases, leading to cell death.
Caspase requirement for neuronal apoptosis and neurodegeneration.
The caspase activity was determined by means of the colorimetric assay according to the extent to acetyl-AspGlu-Val-Asp-nitroanilide and acetyl-Leu-Glu-His-Asp p-nitroanilide, respectively.
Classification of human caspase is based on their function, size of their prodomain, and cleavage activity.
In conclusion, our results demonstrate that specific chemical inhibitors targeting NAMPT sensitize GBM cells to TMZ treatment, evidenced by their synergistic actions on the cell viability, cell death, and apoptotic enzymes activity (caspase family).
MVECs were grown to a monolayer in a 96-well plate (2 x [10.sup.4] cells/well) and treated with 100 ng/ml of recombinant mouse TRAIL (Peprotech), 100 nM second mitochondria-derived activator of caspase (SMAC) mimetic compound (SMC, GDC-0152, Selleckchem), 50 [micro]M zIETD-fmk, 20 [micro]M Necrostatin-1s (Nec-1s), and 50 [micro]M PARP-1 inhibitor 3-aminobenamide (3-ABA, Calbiochem).
ASC recruits procaspase-1 through its C-terminal caspase recruitment domain (CARD) and interacts with NLRP3 via its pyrin domain (PYD), serving as a bridge between these two molecules.

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