are proteolytic enzymes that can cause cell death by apoptosis, necrosis, and inflammation.
Currently most anti-cancer therapies (chemotherapy, radiation and immunotherapy) work by killing cancer cells through a process called apoptosis, which activates proteins called caspases
, leading to cell death.
requirement for neuronal apoptosis and neurodegeneration.
MCF-7 cancer cell lines are characterized by resistance chemotherapeutic agents, [17,18] responsive estrogen receptors (ER+), overexpression of Bcl-2, [19,20] and with no expression of Caspase
The apoptosis mechanism was analyzed with caspase
Then, a homotypic interaction between the N-terminal pyrin domain of NLRP3 and ASC, and subsequently between the caspase
activation and recruitment domain of the ASC and pro-caspase
-1, will recruit pro-caspase
-1 to the high molecular weight complex, leading to its auto-cleavage and activation.
Orrenius, Dual regulation of caspase
activity by hydrogen peroxide: implications for apoptosis.
Apoptosis manifests in two major execution programs, downstream of the death signal: The caspase
pathway  and upstream of irreversible cellular damage reside in the Bcl family members, which are proteins with both proapoptotic and antiapoptotic properties, playing a pivotal role in life and death of [beta]-cells (Figures 1 and 2) [6,12].
3 is an "effector" marker; associated with initiation of apoptotic signaling pathway.
are an unexplored yet attractive target to modulate apoptotic cell death in atherosclerosis, we chose to examine the impact of caspase
-3 deletion on atherosclerosis by crossbreeding caspase
-3 knockout ([Casp3.
Also, fungus polysaccharide extracted from Armillaria mellea revealed a chemopreventive effect on A549 non-small cell lung cancer cells via increment of apoptosis and caspase
activation through intrinsic pathway (23)
If there were a therapeutic way to express, deliver, or induce caspase
4 and 5, humans would not get Legionella infection.