caspase


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Related to caspase: Caspase 3, Caspase 9

caspase

(ˈkæspeɪz)
n
a type of enzyme that is involved in apoptosis and necrosis
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.caspase - any of a group of proteases that mediate apoptosis
peptidase, protease, proteinase, proteolytic enzyme - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
References in periodicals archive ?
Caspases are proteolytic enzymes that can cause cell death by apoptosis, necrosis, and inflammation.
Currently most anti-cancer therapies (chemotherapy, radiation and immunotherapy) work by killing cancer cells through a process called apoptosis, which activates proteins called caspases, leading to cell death.
Caspase requirement for neuronal apoptosis and neurodegeneration.
MCF-7 cancer cell lines are characterized by resistance chemotherapeutic agents, [17,18] responsive estrogen receptors (ER+), overexpression of Bcl-2, [19,20] and with no expression of Caspase 3.
Then, a homotypic interaction between the N-terminal pyrin domain of NLRP3 and ASC, and subsequently between the caspase activation and recruitment domain of the ASC and pro-caspase-1, will recruit pro-caspase-1 to the high molecular weight complex, leading to its auto-cleavage and activation.
Orrenius, Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis.
Apoptosis manifests in two major execution programs, downstream of the death signal: The caspase pathway [14] and upstream of irreversible cellular damage reside in the Bcl family members, which are proteins with both proapoptotic and antiapoptotic properties, playing a pivotal role in life and death of [beta]-cells (Figures 1 and 2) [6,12].
Because caspases are an unexplored yet attractive target to modulate apoptotic cell death in atherosclerosis, we chose to examine the impact of caspase-3 deletion on atherosclerosis by crossbreeding caspase-3 knockout ([Casp3.
Also, fungus polysaccharide extracted from Armillaria mellea revealed a chemopreventive effect on A549 non-small cell lung cancer cells via increment of apoptosis and caspase activation through intrinsic pathway (23)
If there were a therapeutic way to express, deliver, or induce caspase 4 and 5, humans would not get Legionella infection.

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