The comparative pathology of the glycosidase inhibitors swainsonine, castanospermine
, and calystegines A3, B2, and C1 in mice.
Kang et al., "Anti-HIV activity of castanospermine
analogues," The Lancet, vol.
australe contain an alkaloid castanospermine and are known to be toxic to animals, especially horses, and have on occasion been responsible for human poisonings, although it becomes edible when carefully prepared by pounding into flour, leaching with water, and roasting [6, 7].
Jewess et al., "Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe," Phytochemistry, vol.
A highly fatal toxin causing paralysis of the skeletal musculature, 2-(1-hydroxyalkyl) piperidine is a recurrent unit in many alkaloids such as Homopumiliotoxin 223 G 2, Slaframine 3, and Castanospermine
4 (Figure 1).
australe contain an indolizidine alkaloid castanospermine, a trihy-droxyindolizidine alkaloid 7-Deoxy-6-epi-castanospermine and a pyrrolizidine alkaloid Australine which have been shown to inhibit several glucosidases (Orwa et al.
The dry CAS extract powder mainly contains alkaloids castanospermine (RT=10.91), 7-Deoxy-6-epi-castanospermine (RT=7.04) and Australine (RT=21.55).
Effects of the anti-inflammatory compounds castanospermine
, mannose-6-phosphate and fucoidan on allograft rejection and elicited peritoneal exudates.
Celgosivir (rapidly converted to castanospermine
) is currently undergoing clinical trials.
The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine
5 NATURE that the drugs castanospermine
and 1-deoxynojirimycin (dNM) hinder HIV's ability to infect monocytes and lymphocytes in cell cultures by at least 100-fold.
Inhibition of experimental metastasis by castanospermine
in mice: blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors.