This enabled catabolites
and some other toxic substances to cross the membrane when this fluid was instilled in the abdomen.
The K value was determined by the ratio between the total amount of HxR and Hx and the total amount of ATP and its degradation catabolites
in muscle, according to the formula proposed by SAITO et al.
 Ergoreceptors activation has been subject of several recent studies in heart failure syndrome, where metabolic abnormalities in skeletal muscles with early acidosis and accumulation of catabolites
on exercise have been shown to be responsible for their enhanced activity.
The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites
(TRYCATs), both of which contribute to the onset of depression.
Additionally, caffeine along with its catabolites
, theobromine and xanthine, has a structure similar to uric acid, which is an antioxidant compound.
The gut microbiota plays an important role in the metabolism and biotranformation of curcumin into a range of catabolites
In this way, the depletion of tryptophan and the accumulation of immunosuppressive tryptophan catabolites
do impair T cell activation and proliferation inducing anergy and apoptosis .
Alterations in tryptophan (Trp) metabolism are among the best characterized given the immunomodulatory role of Trp and its catabolites
You et al., "The combined effects of tryptophan starvation and tryptophan catabolites
downregulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells," The Journal of Immunology, vol.
It is a recombinant form of carboxypeptidase G2 which is a bacterial enzyme that cleaves methotrexate into two catabolites
. These catabolites
are much less toxic than the parent compound and are excreted hepatically .
Also, the composition of the microbiota determines the levels and nature of tryptophan catabolites
, which in turn have profound effects on epithelial barrier integrity.
Parathyroid hormone levels may also be associated with poor sleep.5 Tryptophan reducing enzyme indoleamine-2,3-dioxygenase causes tryptophan catabolites
increase in HD patients.