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Decreased host defenses, specifically neutropenia (cyclic, congenital, or acquired), are associated with an increased incidence of spontaneous gas gangrene due to C septicum; these cases are also commonly associated with the presence of a necrotizing enterocolitis, cecitis, or distal ileitis.
difficile cecitis (inflammation of the cecum) within 21 days of stopping therapy whereas none of the rifaximin-treated animals had such a relapse.