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Of, relating to, or producing a toxic effect on cells.

cy′to·tox·ic′i·ty (-tŏk-sĭs′ĭ-tē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌsaɪ toʊ tɒkˈsɪs ɪ ti)

cell destruction caused by a cytotoxin.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cytotoxicity - the degree to which something is toxic to living cells
toxicity - the degree to which something is poisonous
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


n. citotoxicidad, la capacidad de un agente de destruir ciertas células.
English-Spanish Medical Dictionary © Farlex 2012
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References in periodicals archive ?
FPA150 is designed with a dual mechanism of action: blocking the T cell checkpoint activity of B7-H4 as well as promoting enhanced antibody-dependent cell-mediated cytotoxicity against tumor cells expressing B7-H4.
Ofatumumab acts by complement-dependent and antibody-dependent cell-mediated cytotoxicity by binding to a small different epitope of CD20, and is currently an approved intravenous drug for use in chronic lymphocytic leukemia (3).
The assessment also included in vitro and in vivo complement-dependent cytotoxicity and antibody-dependent T cell-mediated cytotoxicity tests, and efficacy studies using a colon carcinoma model in a human CTLA-4 transgenic mouse.
Avelumab has been shown to induce NK cell-mediated direct tumour cell lysis via antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro.
FPA150 has a dual mechanism of action: it blocks a T cell checkpoint pathway and delivers antibody-dependent cell-mediated cytotoxicity against B7-H4-expressing tumor cells.
Hughes et al., "Tyrosine kinase inhibitors as modulators of trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity in breast cancer cell lines," Cellular Immunology, vol.
Although the precise mechanism of TCMR is still unclear, cell-mediated cytotoxicity of parenchymal cells and local cytokine release are two possible causes [6].
The cytokines released from activated T cells accumulate inflammatory cells in the region, and this leads to cell-mediated cytotoxicity and keratinocyte destruction.
The percentage of cell-mediated cytotoxicity was determined by the following equation:
As described for MDS, both innate and adaptive immunities are eluded by AML blasts through different mechanisms: (1) suppression of NK cell-mediated cytotoxicity by the inability to lyse AML cells, production of cytotoxic cytokines, aberrant expression of VEGFC, and by immature NK cell inhibition of T cell activation.
Radiation-induced expression led to enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) when breast cancer cells were treated with trastuzumab.