The collaborative research project, entitled HybridADCC, will identify novel monoclonal antibodies and develop an innovative and standardized test that measures the ability of therapeutic antibodies to destroy tumour cells (or infected cells) through a mechanism of toxicity called Antibody - Dependent Cell-mediated Cytotoxicity
Darzalex is believed to induce tumor cell death through multiple immune-mediated mechanisms of action, including complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity
and antibody-dependent cellular phagocytosis, as well as through apoptosis, in which a series of molecular steps in a cell lead to its death.
The percentage of cell-mediated cytotoxicity
was determined by the following equation:
MCLA-128 is a full-length IgG bispecific antibody with enhanced antibody-dependent cell-mediated cytotoxicity
(ADCC) activity targeting HER2 and HER3 receptors.
The main advantages of monoclonal antibodies in comparison to small-molecule drugs are longer half-life, high-affinity binding to target molecules, the possibility of the development of specific mAbs for a wide range of antigens, and the ability to use the host's immune-system effector functions such as antibody-dependent cell-mediated cytotoxicity
(ADCC) and complement-dependent cytotoxicity (CDC) [2,3].
Avelumab is also thought to help white blood cells such as natural killer (NK) cells find and attack tumors in a process known as ADCC, or antibody- dependent cell-mediated cytotoxicity
RTX binding to CD20 initiates B-cells apoptosis, complement dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity
further enhance the therapeutic properties of SIMPLE Antibody leads in terms of tissue penetration/residence time in the body, ability to clear disease targets or pathogenic antibodies and cell-killing potency through Antibody-Dependent Cell-mediated Cytotoxicity
Flow cytometric mast cell-mediated cytotoxicity
assay: a new three-color flow cytometric approach using monoclonal antibody staining with annexin v/propidium iodide co-labeling to assess human mast cell-mediated cytotoxicity
by fluorosphere-adjusted counts.
In conclusion hydatid fluid (HF) can stimulate the differentiation of T lymphocytes into Treg cells and induce the secretion of TGF-AY which could be involved in the suppression of NK cell-mediated cytotoxicity
and the reduction of NKG2D receptor expression.
Dean Bottino, Head Modeling & Simulation Oncology, Roche Pharmaceuticals, will present a webinar entitled “Multi-scale modeling to optimize the antitumor effect of antibody-dependent cell-mediated cytotoxicity
(ADCC) enhanced therapies” on Wednesday, June 19, 2013 at 1:00 - 2:00 pm EDT.