No such relationship was observed between each estimated parameter and chromosome length in centimorgans
. We estimated predicted [r.sup.2] by distance of SNP pairs using our estimated parameters a and b in Equation (2) and compared predicted [r.sup.2] with observed [r.sup.2] as performed in other studies [17,18].
The antigens of the HLA system are determined by genes present in the major histocompatibility complex which is located on the short arm at the 6th chromosome (6p21.3) in humans and extends over some 4 centimorgans
of DNA, about 4 x[10.sup.6] base pair.
Genetic distances were converted from recombination fractions into centiMorgans
(cM) according to Kosambi (1943).
DEKKERS (2004) suggested that, due to the LD extension seen in the entire genome in animal populations of zootechnical interest, informative markers every 1 or 2 centimorgans
(cM) may be sufficient to detect most of the QTLs affecting production traits.
Matches are based on centimorgans
(cM)--the unit of gene measurement.
Second, the recombination rate of DMD is about 4 times higher than the recombination rate with chromosome X and with the whole genome: 4.73 centimorgans
(cM)/Mb, 1.21 cM/Mb, and 1.26 cM/Mb, respectively (21, 22).
Recombination rate estimates were converted to genetic distances in centiMorgans
(cM) using the Kosambi mapping function.
A genome of 2,000 centimorgans
in length was simulated in current research for the characteristic determined by 200 loci with two alleles per locus.
This represents a substantial improvement over standard mapping strategies, which yield only statistically based confidence intervals on the order of 10 to 30 centiMorgans
(cM), corresponding to about 20 to 50 Mb in mice (Glazier et al.
El gen del FIX se encuentra un poco mas hacia el centromero en Xq27.2, separado del gen del FVIII por 0.5 centimorgans
(cM); es menos complejo, tiene 34 kb de longitud, se compone de 8 exones (a-h), codifica un ARN mensajero (ARNm) de 1.4 kb y aunque existe una amplia gama de mutaciones, las mas frecuentes son las puntuales (2).