beta-lactamase

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be·ta-lac·ta·mase

 (bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

[beta-lactam, cyclic amide occurring in penicillins (beta + lact(one) + am(ide)) + -ase.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.beta-lactamase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

be·ta-lac·ta·mase

a. beta-lactamasa, enzima que destruye el conjunto de beta-lactam antibióticos penicílicos haciéndolos no efectivos;
beta-lactamase resistanceresistencia de beta-lactamasa, a algunos tipos de penicilina.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
Relebactam protects imipenem from degradation by certain serine beta lactamases such as Sulhydryl Variable, Temoneira, Cefotaximase-Munich (CTX-M), Enterobacter cloacae P99, Pseudomonas-derived cephalosporinase, and Klebsiella-pneumoniae carbapenemase.
Probably, the resistance in imipenem-resistant strains which are MBL negative is associated with other mechanisms such as activation of efflux pumps, decreasing outer membrane permeability (porin) and high-level AmpC cephalosporinase production.
Additionally, the association of ISAba1 element with [bla.sub.OXA]-type genes and with the chromosomal Acinetobacter derived cephalosporinase (ADC) was also investigated by PCR.
cloacae to third-generation cephalosporins is caused by its overproduction of the AmpC [beta]-lactamases when the production of this cephalosporinase is inducible in the presence of strong [beta]-lactam antibiotics (cefoxitin and imipenem); thus, treatment with third-generation cephalosporins may promote the development of AmpC-overproducing mutants.
blaTEM was the most common [beta]-lactamase gene followed by [bla.sub.CTX-M-1], which was found to be the most frequent type of cephalosporinase conferring resistance to third generation cephalosporins especially to cefotaxime.
Beta-lactam antibiotic resistance among gram negative bacteria to antibiotics is often associated with the production of hydrolytic enzymes particularly extended spectrum [beta]-lactamases (ESBLs), class C cephalosporinase (AmpC), and carbapenemases (including Metallo-beta-lactamases) [35].
coli to amoxicillin; clavulanic acid is the result of hyperproduction of TEM-[beta] lactamase, production of penicillinase resistant to inhibitors, and production of cephalosporinase [10], ampicillin 50% versus 40%, and tetracycline 50% versus 20%.
When genotypic tests find a gene encoding a carbapenemase, cephalosporinase, or ESBL but the isolate is susceptible to the corresponding drug, the enzyme detected may be non-functional or may not currently be expressed by the isolate.
Cephalosporin also come under the category of AY lactams there are five generations of this antibiotic and many of its members are active against bacteria although bacteria harboring the enzyme cephalosporinase confer resistance to this class of antibiotics too.