Genetic characterization of an extended-spectrum AmpC cephalosporinase
with hydrolysing activity against fourth-generation cephalosporins in a clinical isolate of Enterobacter aerogenes selected in vivo.
CTX-M-1], which was found to be the most frequent type of cephalosporinase
conferring resistance to third generation cephalosporins especially to cefotaxime.
Three Yersinia enterocolitica AmpD homologs participate in the multi-step regulation of chromosomal cephalosporinase
Moreover, they possess inducible, chromosomally encoded AmpC cephalosporinase
belonging to Ambler class C enzymes .
Cephalosporin also come under the category of AY lactams there are five generations of this antibiotic and many of its members are active against bacteria although bacteria harboring the enzyme cephalosporinase
confer resistance to this class of antibiotics too.
Extended-spectrum AmpC cephalosporinase
in Acinetobacter baumannii: ADC-56 confers resistance to cefepime.
However, a combination of a new cephalosporinase
and penicillinase provides inactivation of a broad spectrum of 13-lactam antibiotics, including cephalosporins of the third and fourth generation.
Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase
, ADC-7 [beta]-lactamase: defining a unique family of Class C enzymes.
inhibited by clavulanic acid; carbapenemases inhibited by clavulanic acid) Oxacillin-hydrolyzing, OXA; cloxacillin; ESBL cephalosporins; weak activity for carbapenems (e.
aeruginosa is an inducible cephalosporinase
that confers resistance to all betalactams except the carbapenems.
Tran, Q T , Dupont, M , Lavigne, J P , Chevalier, J , Pages, J M , Sotto, A , Anne Reglil, D 2009 Occurrence of Efflux Mechanism and Cephalosporinase
1 Variant in a Population of Enterobacter aerogenes and Klebsiella pneumoniae Producing Extended-Spectrum a-Lactamases Antimicrobials Agents and Chemotherapy On line doi:10 1128/ AAC 00822-08
alteration of penicillin binding site, beta-lactamase and extended-spectrum beta-lactamase-producing organisms via chromosomal-inducible enzymes and cephalosporinase
, ribosomal site alteration, efflux mediated mef E (high level) and target modifiable erm AM mediated (low level) resistance, alteration in the binding site of a specific transpeptidase (mec A) in methicillin-resistant S.