Although DWM and mood symptoms might be observed together coincidentally in our case, cerebellar dysfunction
due to DWM might be effective in the emergence of mood symptoms.
The clinical picture parallels the pathophysiology with symptoms of basal ganglia (10 to 100%), cerebellar dysfunction
(18 to 73%) and liver dysfunction (18 to 84%).
3) Focal neurologic findings are uncommon, but cerebellar dysfunction
, pyramidal dysfunction, and psychiatric symptoms have been reported.
1) Growth is slow and there is no reported malignant potential with clinical presentation typically entailing signs of increased intracranial pressure, obstructive hydrocephalus, and cerebellar dysfunction
Twelve (12/18) patients had memory deficits, 11 (11/18) patients had personality change, 7 (7/18) patients had disturbance of consciousness, and 3 (3/18) patients showed cerebellar dysfunction
Myeloradiculopathy, myelopathy, cerebellar dysfunction
, transverse myelitis, Guillain-Barre syndrome, optic neuritis, peripheral neuropathy have also been described.
While the signs of cerebellar dysfunction
had started acutely, their continuation for more than 2 weeks prompted further investigation for an inherited cause of progressive chronic ataxia (our differential diagnosis included ataxia telangiectasia (no telangiectasia were present clinically and the immunoglobulin levels were normal), abetalipoproteinaemia, Friedreich's ataxia and spinocerebellar ataxia.
The sudden onset of cerebellar dysfunction
symptoms, history of smoking, the absence of apparent risk factors except transient ischemic attack, diagnosis of SCLC, and absence of any other clinical picture that could explain the clinical signs and findings after all examinations, including cranial MRI and CT, suggested the diagnosis of PCD in our first case.
No players in the study had dysarthria, Parkinson's Disease or cerebellar dysfunction
Adult onset disease is characterized by slowly progressive ataxia, spasticity, cerebellar dysfunction
or peripheral neuropathy with relative preservation of intellect.
Because motor functions are coordinated by the cerebellum, it is likely that the high degree of cerebellar dysfunction
may have masked any clinical signs associated with cortical dysfunction.
The Neanderthal movements were clumsy owing to cerebellar dysfunction
as happens in autism.