monotherapy-induced muscle weakness, rhabdomyolysis and acute renal failure.
Examples include cholesterol drugs cerivastatin
(Baycol) and simvastatin (Zocor).
Few examples are benoxaprofen, cerivastatin
, cisapride, domperidone (injectable), valdecoxib, and sibutramine.
, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study.
Sugiyama, "Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin
and cyclosporin A," The Journal of Pharmacology and Experimental Therapeutics, vol.
The studies which were included in this meta-analysis should meet the following criteria: (1) the design of studies should be controlled strictly, including case-control studies, cohort studies, and RCTs; (2) no prior diagnosis of any cancer prior to the date of cancer diagnosis; (3) studies should specific one or more types of statins, including rosuvastatin, atorvastatin, simvastatin, pravastatin, fluvastatin, cerivastatin
, and lovastatin; (4) studies should be designed to evaluate the impact of statins on the risk of cancers with T2DM; (5) studies should have provided sufficient information to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
A retrospective review of the FDA Adverse Event Reporting System (AERS) database found that 88% of fibrate and statin combinations that resulted in rhabdomyolysis were associated with gemfibrozil/cerivastatin (cerivastatin
is no longer available in the United States).
Redmond, "Statin (cerivastatin
) protects mice against sepsis-related death via reduced proinflammatory cytokines and enhanced bacterial clearance," Surgical Infections, vol.
was previously one of the most commonly implicated statin [4,11].
Renzo, "Hypercoagulable state inhypercholesterolemic subjects assessed by platelet dependent thrombin generation: in vitro effect of cerivastatin
, European review formedical and pharmacological sciences," 'European Review Formedical And Pharmacological Sciences, vol.
Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin
. FASEB J 2002; 16: 1928-30.
Several medicines were withdrawn from the market due to their interaction with other substances (mainly related to the CYPs) for example: Seldane[R] (Terfenadine, Aventis Pharmaceuticals, USA), Posicor[R] (Mibefradil, Roche, Switzerland), Propulsid[R] (Cisapride, Janssen-Ortho, Canada), Lotronex[R] (Alosetron, Prometheus Laboratories Inc., USA), Baycol[R] (Cerivastatin
, Bayer A.G., Germany) and Serzone[R] (Nefazodone, Bristol-Myers Squibb, USA) (25).