Acute pancreatitis was induced in rats in groups 3 and 4 with the infusion of glycodeoxycholic acidinto the biliopancreatic canal and infusion of cerulein
(99-101) Mice deficient in T7 trypsinogen exhibit a marked reduction in activation of trypsinogen but nevertheless exhibit comparable levels of acute and chronic experimental pancreatitis induced by repeated injections of cerulein
, a cholecystokinin receptor (CCKR) agonist as observed in wild type mice.
Xu and colleagues (2015) reported using this model in mice exposed to alcohol and given injections of cerulein
. The mice developed fibrosis and had an increased level of cancerous lesions.
reported that the serum levels of miR9 increased significantly in a mouse AP model induced by intraperitoneal injection of cerulein
Severe acute pancreatitis (SAP) was induced in rats by intraperitoneal injections of cerulein
at intervals of 1 h for five times .
Oxidative stress and inflammatory signaling in cerulein
AR42J cells (1million/mL) were divided into the following groups: normal group (NG), in which cells were cultured in medium alone; inflammation group (IG), in which cells were cultured in medium containing cerulein
; and treatment groups one (T1), two (T2), and three (T3), in which cells were cultured in medium containing cerulein
and 479,119.8, and 29.9 [micro]g/L rhein, respectively.
Cerulein-treated mice were composed of mice intraperitoneally injected with cerulein
(Sigma, St Louis, Mo), a cholecystokinin analogue, 7 times on day 0 (dosage, 50 mg/g every hour) to make an acute pancreatitis model.
These scientists developed an in vitro experimental model that allowed them to evaluate how changes in the membrane fatty acid composition in vivo -caused by a change in the type of fat ingested- affect the ability of cells to respond to induced oxidative-inflammatory damage with cerulein
Similarly, cftr(-/-) mice showed constitutive expression of proinflammatory cytokines and developed more severe pancreatitis episodes after cerulein
Miura et al., "Xanthine oxidase-mediated in response to cerulein
in intracellular oxidative stress rat pancreatic acinar cells," Pancreas, vol.
Chen et al., "Knockdown of GRP78 promotes apoptosis in pancreatic acinar cells and attenuates the severity of cerulein
and LPS induced pancreatic inflammation," PLoS ONE, vol.