The global botulinum toxin market is expanding at a high pace owing to the increase in prevalence of cervical dystonia
and upper limb and lower limb spasticity.
Eisai's medicines in Europe include Aricept[R] (donepezil hydrochloride) used in the treatment of Alzheimer's disease, Pariet[R] (rabeprazole sodium) a proton pump inhibitor (PPI) used in the treatment of gastro-intestinal disorders, Zonegran[R] (zonisamide) for the treatment of epilepsy, Inovelon[R] (rufinamide) for Lennox Gastaut Syndrome, NeuroBloc[R] (botulinum toxin type B) for cervical dystonia
and Prialt[R] (ziconotide) for severe, chronic pain.
To date, the FDA has approved Botox to treat nine medical conditions including overactive bladder, cervical dystonia
and eye-muscle disorders, though off-label use by physicians has come to include literally hundreds of conditions, ranging from sweaty palms to depression to erectile dysfunction.
Benign essential blepharospasm (BEB) is the second most common focal dystonia after cervical dystonia
which is caused by involuntary contraction of orbicularis oculi, procerus and neighbouring corrugator muscles (1,2).
Five days earlier, she had received botulinum toxin A injections using Food and Drug Administration (FDA)-approved doses for cervical dystonia
at office A under electromyography guidance.
Pooled Safety Analysis of Randomized, Prospective Studies on IncobotulinumtoxinA for the Treatment of Cervical Dystonia
, Blepharospasm, and Upper Limb Spasticity
It may also improve pain in cervical dystonia
. Effects of stimulation are not seen immediately but it takes some time.
The 13 abstracts will present neuroscience data that advances knowledge in physical and rehabilitation medicine including clinical outcomes linked to Ipsen's portfolio in adult spasticity (upper and lower limbs), pediatric spasticity, and in cervical dystonia
. In addition, an international survey investigating the burden of spasticity on patients and their caregivers will be presented, as well as real-world data that supports better understanding of current clinical practices.
According to the company, XEOMIN (incobotulinumtoxinA) is a prescription medicine that is injected into muscles or glands and used to treat adults with sialorrhea, increased muscle stiffness in the arm of adults with upper limb spasticity, the abnormal head position and neck pain that happens with cervical dystonia
(CD) in adults, and to treat abnormal spasm of the eyelids (blepharospasm) in adults who have had prior treatment with onabotulinumtoxinA (Botox).
Idiopathic (primary) cervical dystonia
(CD) is a coercive undesirable pathology characterized by involuntary sustained or intermittent contractions of the muscles of the neck causing twisting movements and abnormal head and neck postures (1-3).