chelator


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Related to chelator: chelate compound, EDTA, Chelant

che·late

 (kē′lāt′)
adj. Zoology
Having chelae or resembling a chela.
n. Chemistry
A chemical compound in the form of a heterocyclic ring, containing a metal ion attached by coordinate bonds to at least two nonmetal ions.
tr.v. che·lat·ed, che·lat·ing, che·lates
1. Chemistry To combine (a metal ion) with a chemical compound to form a ring.
2. Medicine To remove (a heavy metal, such as lead or mercury) from the bloodstream by means of a chelate, such as EDTA.

che′lat·a·ble adj.
che·la′tion n.
che′la′tor n.

chelator

(kiːˈleɪtə)
n
an organic chemical that bonds with metal ions and produces a chelate compound
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References in periodicals archive ?
Deferasirox tablets for oral suspension are an iron chelator indicated for the treatment of chronic iron overload due to blood transfusions in patients two years of age and older.
All chemicals used in the synthesis of chelator throughout analytical process were of analytical grade.
Under the supervision of Dr Ibrahim Mustafa, students Nahjeha Rizwan and Waad Elkhair studied the effect of macromolecular iron chelator (Deferoxamine covalently attached to a starch backbone) on platelets in hopes of finding a manner to reduce the toxicity of iron chelators used in thalassemia therapy.
Nahjeha Rizwan and Waad Elkhair under the supervision of Dr Ibrahim Mustafa studied the effect of macromolecular iron chelator (Deferoxamine covalently attached to a starch backbone) on platelets aiming to find a manner to reduce the toxicity of iron chelators used in the thalassaemia therapy.
Novartis launched an injectable iron chelator in 1968.
However, it should be noted that the amount of smear increases from the coronal one-third toward the apical one-third, regardless of the chelator, as stated in the studies of Schmidt et al.
DMSA or Meso-2,3-dirnercaptosuccinic acid has been used as a heavy metal chelator since the 1950s, and was extensively researched in the People's Republic of China, Japan, and Russia before it spread to Europe and the USA.
In this study, we hypothesized that in addition to the well-investigated molecular mechanisms for iron and the action of an iron chelator, DFO, their activity may be associated with regulating intracellular calcium.
N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) is a membrane-permeable hexadentate compound which chelates metal ions such as [Cu.sup.2+], [Zn.sup.2+], and [Fe.sup.2+] [1,2], but this intracellular chelator has shown a high affinity for zinc [3-5].
The EDTA (standard chelator) produced to a significant (p [less than or equal to] 0.01) effect (97 %) compared to the control.