The weak chelators
aren't necessarily safe either, since a chelator
doesn't just work by itself or with a piece of metal, but within an individual human body endowed with its own and already preexisting strengths and weaknesses, including those of the excretory organs.
To test these claims, the Respiratory Toxicology Group has exposed rats to concentrations of mercury vapor that lead to high concentrations in the brain, and then treated them with various combinations of glutathione and vitamin C and with 2,3-dimercapto-propane-1-sulphonate, a chelator
that is known to reduce the amount of mercury in the body.
One of the most commonly used copper chelator
DMSA or Meso-2,3-dirnercaptosuccinic acid has been used as a heavy metal chelator
since the 1950s, and was extensively researched in the People's Republic of China, Japan, and Russia before it spread to Europe and the USA.
In this study, we hypothesized that in addition to the well-investigated molecular mechanisms for iron and the action of an iron chelator
, DFO, their activity may be associated with regulating intracellular calcium.
In the zinc or copper chelating assay, the chelator
were able to capture the ions and inhibit the formation of [Zn.
It is a powerful, recoverable and comparatively biostable chelator
which has the ability to remediate the metal affected soils (Meers et al.
Morphological evidence of ototoxicity of the iron chelator
It is reported in some recent studies that a naturally present flavolignan and Silybin extracted from the fruits of silibiummarianum possess some antioxidant and radical scavenging abilities that works as an iron chelator
(Borsari et al.
If only the fast-acting chelator
, BAPTA, can inhibit exocytosis and synaptic transmission, but the slow chelator
EGTA cannot, tight coupling is at work, while in loose coupling, both fast and slow chelators
can inhibit transmission.
We compared 2 NTBI assays: a labile plasma iron (LPI) assay that uses desferrioxamine as the iron chelator
(3) and a microwell modification of a bleomycin-detectable iron (BDI) assay (2).
8) As divalent metals are needed to make the dimeric structure more stable, a chelator
agent would affect the activity of such enzymes.