- The report provides a snapshot of the global therapeutic landscape for C-X-C Chemokine
Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2)
We evaluated the concentrations of a select panel of cytokines, including innate immune mediators (interferon [IFN]-[gamma], interleukin [IL]-15, IFN-P); inflammatory factors (IL-6, IL-18, soluble intercellular adhesion molecule 1 [sICAM-1]); chemokines
ligand [CCL] 3, CCL-4, CXC-motif chemokine
ligand [CXCL] 1, CXCL-8, CXCL-10); hematopoietic factors (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor); the angiogenic factor vascular endothelial growth factor A (VEGF-A); and proteases (matrix metalloproteinase [MMP]-2, MMP-9).
LOW-DOSE TREATMENT with plerixafor, a CXC chemokine
receptor 4 antagonist, was well tolerated and markedly improved severe presentations of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome in three patients who could not receive granulocyte colony-stimulating factor (G-CSF) therapy.
ChemoCentryx announced presentations of its lead drug candidates avacopan, a complement 5a receptor inhibitor, and CCX140, an inhibitor of the chemokine
receptor known as CCR2, during the American Society of Nephrology, ASN, Kidney Week 2018, the world's premier nephrology meeting, being held October 23-28 in San Diego.
To further study the expression profiles of CC family members and the immune-regulatory mechanisms of large yellow croaker, this study reports the molecular characteristics and expression profile of three genes (dual chemokine
ligand CCL17 and homeostatic chemokines
ligands CCL21 and CCL24) following bacterial challenge.
Eotaxin2 (CCL24), a member of the CC chemokine
family, is a potent chemoattractant for eosinophils, basophils, and lymphocytes, distributed in a variety of tissues, including human brain .
Altered host defense is a hallmark of COPD that is characterized by local (lung) as well as systemic alterations of cytokine and chemokine
Peripherally activated lymphocytes are rarely able to traffic to mucosal sites due to low, or lack of expression, specific adhesion and chemokine
receptors required for entry into these sites.
Background and Objective: Atypical chemokine
receptor 1(ACKR1) represents an atypical chemokine
receptor that can bind promiscuously to various chemokines
We found that in addition to TNF-a, the proinflammatory chemokine
ligand 3 (CCL3) also was downregulated by rolipram whereas the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1Ra) was upregulated.
The initial step in membrane fusion begins with binding of the viral envelope protein (Env, consisting of a trimer of gp120-gp41 heterodimers) to the [CD4.sup.+] cell surface protein and a chemokine
co-receptor present on the host cell.