chemokine


Also found in: Medical, Encyclopedia, Wikipedia.
Related to chemokine: cytokine, interleukin, Chemokine receptor

che·mo·kine

 (kē′mō-kīn′, kĕm′ō-)
n.
Any of various chemotactic cytokines that are released by several cell types and act to attract monocytes, neutrophils, and other white blood cells to sites of injury or inflammation.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

chemokine

(ˈkiːməʊˌkaɪn)
n
a type of protein produced during inflammation that activates white blood cells
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
- The report provides a snapshot of the global therapeutic landscape for C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2)
We evaluated the concentrations of a select panel of cytokines, including innate immune mediators (interferon [IFN]-[gamma], interleukin [IL]-15, IFN-P); inflammatory factors (IL-6, IL-18, soluble intercellular adhesion molecule 1 [sICAM-1]); chemokines (CC-motif chemokine ligand [CCL] 3, CCL-4, CXC-motif chemokine ligand [CXCL] 1, CXCL-8, CXCL-10); hematopoietic factors (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor); the angiogenic factor vascular endothelial growth factor A (VEGF-A); and proteases (matrix metalloproteinase [MMP]-2, MMP-9).
LOW-DOSE TREATMENT with plerixafor, a CXC chemokine receptor 4 antagonist, was well tolerated and markedly improved severe presentations of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome in three patients who could not receive granulocyte colony-stimulating factor (G-CSF) therapy.
ChemoCentryx announced presentations of its lead drug candidates avacopan, a complement 5a receptor inhibitor, and CCX140, an inhibitor of the chemokine receptor known as CCR2, during the American Society of Nephrology, ASN, Kidney Week 2018, the world's premier nephrology meeting, being held October 23-28 in San Diego.
To further study the expression profiles of CC family members and the immune-regulatory mechanisms of large yellow croaker, this study reports the molecular characteristics and expression profile of three genes (dual chemokine ligand CCL17 and homeostatic chemokines ligands CCL21 and CCL24) following bacterial challenge.
Eotaxin2 (CCL24), a member of the CC chemokine family, is a potent chemoattractant for eosinophils, basophils, and lymphocytes, distributed in a variety of tissues, including human brain [15].
Altered host defense is a hallmark of COPD that is characterized by local (lung) as well as systemic alterations of cytokine and chemokine regulation [18].
Peripherally activated lymphocytes are rarely able to traffic to mucosal sites due to low, or lack of expression, specific adhesion and chemokine receptors required for entry into these sites.
Background and Objective: Atypical chemokine receptor 1(ACKR1) represents an atypical chemokine receptor that can bind promiscuously to various chemokines.
We found that in addition to TNF-a, the proinflammatory chemokine CC chemokine ligand 3 (CCL3) also was downregulated by rolipram whereas the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1Ra) was upregulated.
The initial step in membrane fusion begins with binding of the viral envelope protein (Env, consisting of a trimer of gp120-gp41 heterodimers) to the [CD4.sup.+] cell surface protein and a chemokine co-receptor present on the host cell.
Full browser ?